Abstract：
:Six new methyl angolensate type (1-6) and three new mexicanolide-type (7-9) limonoids, along with six known limonoids (10-15), were isolated from the seeds of Cipadessa baccifera. The structures of all these compounds were established by extensive 1D, 2D NMR, and HRESIMS experiments, and structures of 11 and 13 were further confirmed by a single crystal X-ray diffraction analysis, which are reported for the first time. The cytotoxic activities of these isolates were also studied against A549, MCF7, ME-180, HT-29, B-16, ACHN cancer cell lines using MTT assay, and results indicated that compounds 4, 10, and 14 displayed potent cytotoxic activity against B-16, ACHN cell lines with an IC50 values of 8.51 and 7.0 μg/mL, respectively.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Siva B,Poornima B,Venkanna A,Prasad KR,Sridhar B,Nayak VL,Ramakrishna S,Babu KSdoi
10.1016/j.phytochem.2013.11.006subject
Has Abstractpub_date
2014-02-01 00:00:00pages
174-82eissn
0031-9422issn
1873-3700pii
S0031-9422(13)00438-Xjournal_volume
98pub_type
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