Abstract：
:Twenty phenolic compounds, representatives of proanthocyanidins and gallic acid/hexahydroxyldiphenic acid esters of glucose, have been assessed for their ability to inhibit binding of specific radioligands to 16 receptors. The receptors utilized were alpha 1-, alpha 2- and beta-adrenoceptors, adenosine 1, dopamine 1 and 2, muscarinic, Ca2+ channel, sulphonylureas, 5HT1, 5HT1A, 5HT2, histamine 1, benzodiazepine, opiate and Na+/K/ATPase. These phenolic compounds failed to inhibit ligands binding to 10 of the receptors under the test conditions. The most susceptible receptors to phenolic binding were beta-adrenergic, 5HT1 and opiate. Some of the compounds tested showed selectivity for a single or for two receptors. The inhibition of binding of radioligands to receptors by the phenolic compounds cannot be explained solely in terms of phenolic-protein binding. The results indicate that the removal of tannins from plant extracts prior to screening for receptor activities may result in missing biologically active compounds with specificity of action.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Zhu M,Phillipson JD,Greengrass PM,Bowery NE,Cai Ydoi
10.1016/s0031-9422(96)00598-5subject
Has Abstractpub_date
1997-02-01 00:00:00pages
441-7issue
3eissn
0031-9422issn
1873-3700pii
S0031942296005985journal_volume
44pub_type
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