Abstract:
:Eight ring C-seco and ring-intact limonoids, and 25 known limonoids were isolated from the fruits of Melia toosendan (Meliaceae). Their structures were elucidated on the basis of extensive spectroscopic evidence including HRMS, 1D and 2D NMR spectroscopic data. A total of 29 isolated limonoids was evaluated for NF-κB activities. Among them, eight compounds significantly enhanced the TNFα-induced NF-κB luciferase activity at 10μM, while 10 compounds suppressed the NF-κB activation.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Zhu GY,Bai LP,Liu L,Jiang ZHdoi
10.1016/j.phytochem.2014.08.009subject
Has Abstractpub_date
2014-11-01 00:00:00pages
175-81eissn
0031-9422issn
1873-3700pii
S0031-9422(14)00324-0journal_volume
107pub_type
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