Limonoids from the fruits of Melia toosendan and their NF-κB modulating activities.

Abstract:

:Eight ring C-seco and ring-intact limonoids, and 25 known limonoids were isolated from the fruits of Melia toosendan (Meliaceae). Their structures were elucidated on the basis of extensive spectroscopic evidence including HRMS, 1D and 2D NMR spectroscopic data. A total of 29 isolated limonoids was evaluated for NF-κB activities. Among them, eight compounds significantly enhanced the TNFα-induced NF-κB luciferase activity at 10μM, while 10 compounds suppressed the NF-κB activation.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Zhu GY,Bai LP,Liu L,Jiang ZH

doi

10.1016/j.phytochem.2014.08.009

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

175-81

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(14)00324-0

journal_volume

107

pub_type

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