Abstract:
:Three monoamine oxidase (MAO) inhibitors were isolated from Gentiana lutea. Their structures were elucidated to be 3-3''linked-(2'-hydroxy-4-O-isoprenylchalcone)-(2'''-hydroxy-4''-O-isoprenyldihydrochalcone) (1), 2-methoxy-3-(1,1'-dimethylallyl)-6a,10a-dihydrobenzo(1,2-c)chroman-6-one and 5-hydroxyflavanone. These compounds, and the hydrolysis product of 1, displayed competitive inhibitory properties against MAO-B which was more effective than MAO-A.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Haraguchi H,Tanaka Y,Kabbash A,Fujioka T,Ishizu T,Yagi Adoi
10.1016/j.phytochem.2004.06.025subject
Has Abstractpub_date
2004-08-01 00:00:00pages
2255-60issue
15eissn
0031-9422issn
1873-3700pii
S0031-9422(04)00286-9journal_volume
65pub_type
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