A sesquiterpene drimane with antinociceptive activity from Drimys winteri bark.

Abstract:

:Along with three known drimanes, polygodial. 1-beta-(p-methoxycinnamoyl) polygodial and mukaadial, the sesquiterpene drimane named drimanial was isolated from the bark of Drimys winteri (Winteraceae). Its structure was elucidated based on spectroscopic evidence. Drimanial exhibited antinociceptive action against acetic acid induced pain, being about 3-fold less active than polygodial.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Malheiros A,Filho VC,Schmitt CB,Santos ARS,Scheidt C,Calixto JB,Monache FD,Yunes RA

doi

10.1016/s0031-9422(00)00515-x

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

103-7

issue

1

eissn

0031-9422

issn

1873-3700

pii

S003194220000515X

journal_volume

57

pub_type

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