Abstract：
:Ganoderma lingzhi is a valuable, edible and medicinal fungus that has been widely used for the prevention and treatment of a broad range of diseases. In this study, spirolingzhines A-D, four meroterpenoids with a spiro[benzofuran-2,10-cyclopentane] motif, lingzhines A-F, six meroterpenoids with diverse ring systems, along with two known compounds were isolated from the fruiting bodies of this fungus. The structures and stereochemistry of these substances were determined by using spectroscopic, X-ray crystallographic and computational methods. Chiral HPLC was used to separate (-)- and (+)-antipodes of seven of ten meroterpenoids, which were isolated from the fungus as racemic mixtures. Several of the metabolites were found to promote proliferation of neural stem cells (NSCs) and, as such, they constitute a class of NSC stimulators. The most potent member of this series, (-)-spirolingzhine A, was shown to affect NSC cell cycle progression using the 5-bromo-2-deoxyuridine (BrdU) incorporation assay.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Yan YM,Wang XL,Luo Q,Jiang LP,Yang CP,Hou B,Zuo ZL,Chen YB,Cheng YXdoi
10.1016/j.phytochem.2015.03.013subject
Has Abstractpub_date
2015-06-01 00:00:00pages
155-62eissn
0031-9422issn
1873-3700pii
S0031-9422(15)00125-9journal_volume
114pub_type
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