Abstract：
:Four undescribed pyrone derivatives, pestalopyrones A-D, containing unusual tricyclic 5/6/6 polycyclic skeletons, were isolated from the ethyl acetate extract of the endophytic fungus Pestalotiopsis neglecta S3 derived from the fresh stems of Rubia podantha Diels (Rubiaceae). Their planar structures were elucidated mainly by NMR and HRESIMS. Pestalopyrones A-D contained six contiguous chiral carbons, and the relative configurations of C-4, C-5, and C-8 in tricyclic 5/6/6 polycyclic skeletons were determined by ROESY spectra. For pestalopyrone B, the absolute configuration of C-16 was determined by the Mosher's method. All isolated compounds were tested for their cytotoxicity against cancer cell lines, antibacterial activity, and inhibitory effect on the lipopolysaccharide (LPS)-induced nitric oxide (NO) production, and the results showed that pestalopyrone A inhibited LPS-induced NO production with an IC50 value of 35.8 μM.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Feng L,Han J,Wang J,Zhang AX,Miao YY,Tan NH,Wang Zdoi
10.1016/j.phytochem.2020.112505subject
Has Abstractpub_date
2020-11-01 00:00:00pages
112505eissn
0031-9422issn
1873-3700pii
S0031-9422(20)30514-8journal_volume
179pub_type
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