Immunosuppressive diacetylenes, ceramides and cerebrosides from Hydrocotyle leucocephala.

Abstract:

:Three C-17 diacetylenic compounds (1-3), one monoterpenoid (4), seven ceramides (leucoceramides A-G, 5a-g), six cerebrosides (leucocerebrosides A-F, 6a-f) and nine known compounds were isolated from the methanolic extract of Hydrocotyle leucocephala. Their structures were established by spectroscopic methods. The isolated compounds 1-3, 5a-g, 6a-f and 7 were shown to be active in the lipopolysaccharide (LPS) induced cytokine production assay for IL-10, IL-12, and TNF-alpha.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Ramos F,Takaishi Y,Kawazoe K,Osorio C,Duque C,Acuña R,Fujimoto Y,Sato M,Okamoto M,Oshikawa T,Ahmed SU

doi

10.1016/j.phytochem.2006.03.004

subject

Has Abstract

pub_date

2006-06-01 00:00:00

pages

1143-50

issue

11

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(06)00149-X

journal_volume

67

pub_type

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