Antiplasmodial dimeric chalcone derivatives from the roots of Uvaria siamensis.

Abstract:

:Four dimeric chalcone derivatives, 8″,9″-dihydrowelwitschin H, uvarins A-C, a naphthalene derivative, 2-hydroxy-3-methoxy-6-(4'- hydroxyphenyl)naphthalene, and the known dimeric chalcones, dependensin and welwitschin E, flavonoids, a cyclohexane oxide derivative, an aromatic aldehyde were isolated from the roots of Uvaria siamensis (Annonaceae). The structures of the compounds were elucidated by spectroscopic analysis, as well as by comparison with literature data. The isolated compounds with a sufficient amount for biological assays were evaluated for their antimalarial, antimycobacterial, and cytotoxic activities. The dimeric chalcones 8″,9″-dihydrowelwitschin H, uvarins B and C, dependensin and welwitschin E showed strong antiplasmodial activity with IC50 values of 3.10, 3.02, 3.09, 4.21 and 3.99 μg/mL, respectively. A possible biosynthesis pathway of the dimeric chalcones is discussed.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Salae AW,Chairerk O,Sukkoet P,Chairat T,Prawat U,Tuntiwachwuttikul P,Chalermglin P,Ruchirawat S

doi

10.1016/j.phytochem.2016.12.009

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

135-143

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(16)30294-1

journal_volume

135

pub_type

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