Abstract:
:Four dimeric chalcone derivatives, 8″,9″-dihydrowelwitschin H, uvarins A-C, a naphthalene derivative, 2-hydroxy-3-methoxy-6-(4'- hydroxyphenyl)naphthalene, and the known dimeric chalcones, dependensin and welwitschin E, flavonoids, a cyclohexane oxide derivative, an aromatic aldehyde were isolated from the roots of Uvaria siamensis (Annonaceae). The structures of the compounds were elucidated by spectroscopic analysis, as well as by comparison with literature data. The isolated compounds with a sufficient amount for biological assays were evaluated for their antimalarial, antimycobacterial, and cytotoxic activities. The dimeric chalcones 8″,9″-dihydrowelwitschin H, uvarins B and C, dependensin and welwitschin E showed strong antiplasmodial activity with IC50 values of 3.10, 3.02, 3.09, 4.21 and 3.99 μg/mL, respectively. A possible biosynthesis pathway of the dimeric chalcones is discussed.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Salae AW,Chairerk O,Sukkoet P,Chairat T,Prawat U,Tuntiwachwuttikul P,Chalermglin P,Ruchirawat Sdoi
10.1016/j.phytochem.2016.12.009subject
Has Abstractpub_date
2017-03-01 00:00:00pages
135-143eissn
0031-9422issn
1873-3700pii
S0031-9422(16)30294-1journal_volume
135pub_type
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