Abstract:
:Eleven triterpenoid saponins were isolated from the roots of Gypsophila trichotoma Wender. (G. trichotoma Wender. var. trichotoma) (Caryophyllaceae), together with one known compound. The structures were established on the basis of extensive NMR analysis ((1)H, (13)C NMR, COSY, TOCSY, ROESY, HSQC, and HMBC), completed by analysis of HR-ESI-MS and ESI-MS(n). The saponins have the commonly found gypsogenin as the aglycone substituted at C-3 with trisaccharide and at C-28 with oligosaccharide through a fucose residue, as saponins isolated from Gypsophila perfoliata L. originated from China. The oligosaccharide attached to C-28 is substituted with acetyl and (or) sulfate groups. Тhe cytotoxicity of the saponin extract from G. trichotoma was evaluated against a rat alveolar macrophage-like cell line NR8383 and human leukemia cell lines U937 and BV-173. The synergistic effect of the aminoacyl saponins, previously isolated from G. trichotoma, was tested for its ability to enhance the cytotoxicity of the targeted toxin in HER14 cells.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Voutquenne-Nazabadioko L,Gevrenova R,Borie N,Harakat D,Sayagh C,Weng A,Thakur M,Zaharieva M,Henry Mdoi
10.1016/j.phytochem.2013.03.001subject
Has Abstractpub_date
2013-06-01 00:00:00pages
114-27eissn
0031-9422issn
1873-3700pii
S0031-9422(13)00076-9journal_volume
90pub_type
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