Triterpenoid saponins from the roots of Gypsophila trichotoma Wender.

Abstract:

:Eleven triterpenoid saponins were isolated from the roots of Gypsophila trichotoma Wender. (G. trichotoma Wender. var. trichotoma) (Caryophyllaceae), together with one known compound. The structures were established on the basis of extensive NMR analysis ((1)H, (13)C NMR, COSY, TOCSY, ROESY, HSQC, and HMBC), completed by analysis of HR-ESI-MS and ESI-MS(n). The saponins have the commonly found gypsogenin as the aglycone substituted at C-3 with trisaccharide and at C-28 with oligosaccharide through a fucose residue, as saponins isolated from Gypsophila perfoliata L. originated from China. The oligosaccharide attached to C-28 is substituted with acetyl and (or) sulfate groups. Тhe cytotoxicity of the saponin extract from G. trichotoma was evaluated against a rat alveolar macrophage-like cell line NR8383 and human leukemia cell lines U937 and BV-173. The synergistic effect of the aminoacyl saponins, previously isolated from G. trichotoma, was tested for its ability to enhance the cytotoxicity of the targeted toxin in HER14 cells.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Voutquenne-Nazabadioko L,Gevrenova R,Borie N,Harakat D,Sayagh C,Weng A,Thakur M,Zaharieva M,Henry M

doi

10.1016/j.phytochem.2013.03.001

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

114-27

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(13)00076-9

journal_volume

90

pub_type

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