Abstract：
:During the search for new protein tyrosine phosphatase (PTP) 1B inhibitors, EtOH extracts from the aerial parts of Lantana camara L. (lantana) collected at Manado (Indonesia) and two subtropical islands in Japan (Ishigaki and Iriomote Islands, Okinawa) exhibited potent inhibitory activities against PTP1B in an enzyme assay. Four previously undescribed oleanane triterpenes were isolated together with known triterpenes and flavones from the Indonesian lantana. The EtOH extracts of lantana collected in Ishigaki and Iriomote Islands exhibited different phytochemical profiles from each other and the Indonesian lantana. Triterpenes with a 24-OH group were isolated from the Indonesian lantana only. Five known triterpene compounds were detected in the Ishigaki lantana, and two oleanane triterpenes with an ether linkage between 3β and 25 were the main components together with five known triterpenes as minor components in the Iriomote lantana. The structures of previously undescribed compounds were assigned on the basis of their spectroscopic data. Among the compounds obtained in this study, oleanolic acid exhibited the most potent activity against PTP1B, and is used as a positive control in studies on PTP1B.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Abdjul DB,Yamazaki H,Maarisit W,Rotinsulu H,Wewengkang DS,Sumilat DA,Kapojos MM,Losung F,Ukai K,Namikoshi Mdoi
10.1016/j.phytochem.2017.08.020subject
Has Abstractpub_date
2017-12-01 00:00:00pages
106-112eissn
0031-9422issn
1873-3700pii
S0031-9422(17)30295-9journal_volume
144pub_type
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