Abstract：
:Silene species are known for their use in traditional medicine in treating several diseases. To the authors' knowledge there is no report on the chemical composition of S. odontopetala. Therefore, the phytochemical investigation of the methanol extract of S. odontopetala was carried out, leading to the isolation of six undescribed oleanane-type glycosides along with the known saponin azukisaponin IV. Their structures were elucidated by the analysis of 1D and 2D-NMR experiments, along with mass spectrometry analysis. The cytotoxic activity of oleanane-type saponins was evaluated against a small panel of cancer cell lines, including PC-3 (prostate carcinoma cells), MCF-7 (breast cancer cells), A549 (alveolar basal carcinoma cells), and HeLa (cervical carcinoma cells). Furthermore, the activity of isolated compounds against a normal cell line HEK-293, used for assessing their cytotoxicity, was evaluated.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Ün RN,Masullo M,Karayildirim T,Nalbantsoy A,Alankus O,Piacente Sdoi
10.1016/j.phytochem.2020.112404subject
Has Abstractpub_date
2020-08-01 00:00:00pages
112404eissn
0031-9422issn
1873-3700pii
S0031-9422(19)31034-9journal_volume
176pub_type
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