Abstract：
:Bioassay-guided fractionation against alpha-glucosidase resulted in isolation and characterization of eight active compounds from the EtOH extract of the seeds of Syagrus romanzoffiana. Of these, seven are stilbenoids, and two of them, 13-hydroxykompasinol A (1) and scirpusin C (4), possess potent inhibitory activity against alpha-glucosidase type IV from Bacillus stearothermophilus with the IC50 value of 6.5 and 4.9 microM, respectively. The in vivo assay on normal Wistar rats using oral sucrose challenge also demonstrated that kompasinol A (2) and 3,3',4,5,5'-pentahydroxy-trans-stilbene (5) possess significant effect in reducing the postprandial blood glucose level (10.2% and 12.1% at 10mg/kg, respectively). These results suggest that stilbenoids might be explored for their therapeutic potential as hypoglycemic agents.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Lam SH,Chen JM,Kang CJ,Chen CH,Lee SSdoi
10.1016/j.phytochem.2007.12.004subject
Has Abstractpub_date
2008-03-01 00:00:00pages
1173-8issue
5eissn
0031-9422issn
1873-3700pii
S0031-9422(07)00720-0journal_volume
69pub_type
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