Abstract：
:Seven pairs of undescribed enantiomeric bis-coumarins, (±)-dievodialetins A-G, were separated from the roots of Evodia lepta Merr. Two coumarin nuclei were linked via a 1,4-dimethyl4-vinylcyclohexene moiety in (±)-dievodialetins C-G. The structures of the undescribed compounds, including their absolute configurations were elucidated by spectroscopic analyses, X-ray diffraction, and computational calculations. In the biosynthetic pathways, these bis-coumarins were presumably derived from the precursors demethylsuberosin and 3-(3-methylbut-2-enyl)umbelliferone via a [4 + 2] Diels-Alder reaction. Besides, all compounds exhibited neuroprotective effects by inhibiting acetylcholinesterase (AChE) activity with IC50 values ranging from 7.3 to 12.1 nM and they also suppressed oxidative stress (MDA and SOD) and neuroinflammation (IL-1β and IL-6).
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Huang GY,Cui H,Lu XY,Zhang LD,Ding XY,Wu JJ,Duan LX,Zhang SJ,Liu Z,Zhang RRdoi
10.1016/j.phytochem.2020.112597subject
Has Abstractpub_date
2021-02-01 00:00:00pages
112597eissn
0031-9422issn
1873-3700pii
S0031-9422(20)31212-7journal_volume
182pub_type
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