Abstract：
:Chemical investigation of the traditional Chinese medicine, Murraya kwangsiensis, led to the isolation of 16 undescribed biscarbazole alkaloids, kwangsines A-M, two undescribed natural products, (+/-)-bispyrayafoline C, and 19 known monomeric analogues. (±)-Bispyrayafoline C and (±)-kwangsines A-C are four pairs of biscarbazole atropisomers, and they were separated by chiral HPLC to obtain the optically pure compounds. The structures of the undescribed compounds were elucidated on the basis of HRESIMS and NMR data analysis. Their absolute configurations were assigned via comparison of the specific rotation, ECD exciton coupling method, as well as comparison of experimental and calculated ECD data. A compound showed significant inhibition on NO production in lipopolysaccharide-stimulated BV-2 microglial cells, and four compounds exhibited moderate cytotoxicities against HepG2 cells, with IC50 values less than 20 μM.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Chen Y,Cao N,Lv H,Zeng K,Yuan J,Guo X,Zhao M,Tu P,Jiang Ydoi
10.1016/j.phytochem.2019.112186subject
Has Abstractpub_date
2020-02-01 00:00:00pages
112186eissn
0031-9422issn
1873-3700pii
S0031-9422(19)30578-3journal_volume
170pub_type
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