Abstract：
:Nine pregnane glycosides containing peroxy functions in their sugar moieties (1-5 and 11-14), five oligosaccharides (6-10), six pregnane glycosides (15-20), and five cardiac glycosides (21-25) were isolated from the root barks of Periploca sepium Bge. (Asclepiadaceae) and the roots of Periploca forrestii Schltr. (Asclepiadaceae), two traditional Chinese medicines used for the treatment of rheumatoid arthritis. Among them, 1-8 are hitherto unknown. Their structures were characterized on the basis of spectroscopic analyses. In pharmacological testing, compounds 1-5 and 11-14 were found to exhibit inhibitory activity against the proliferation of T lymphocyte in vitro with IC50 values ranging from 0.29microM to 1.97microM, while the other components showed no significant inhibitory activity.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Feng J,Zhang R,Zhou Y,Chen Z,Tang W,Liu Q,Zuo JP,Zhao Wdoi
10.1016/j.phytochem.2008.08.015subject
Has Abstractpub_date
2008-11-01 00:00:00pages
2716-23issue
15eissn
0031-9422issn
1873-3700pii
S0031-9422(08)00394-4journal_volume
69pub_type
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