Abstract:
:A new cytotoxic 1,7-dioxa-dispiro[5.1.5.2]pentadeca-9,12-dien-11-one derivative, aculeatin D, and a new alkenone, 5-hydroxy-hexacos-1-en-3-one, have been isolated as minor compounds from the rhizomes of Amomum aculeatum. Their structures have been determined mainly by NMR spectroscopy and mass spectrometry. Aculeatin D showed high cytotoxicity against the KB and the L-6 cell line with IC(50) of 0.38 microg/ml and 1 microg/ml, respectively. Additionally, it revealed remarkable activity against two Plasmodium falciparum strains, as well as against Trypanosoma brucei rhodesiense and Trypanosoma cruzi. 5-Hydroxy-hexacos-1-en-3-one exhibited neither cytotoxic nor antiprotozoal activity, whereas antibacterial testing against Bacillus cereus, Escherichia coli and Staphylococcus epidermidis showed moderate to strong activity for both compounds.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Heilmann J,Brun R,Mayr S,Rali T,Sticher Odoi
10.1016/s0031-9422(01)00174-1subject
Has Abstractpub_date
2001-08-01 00:00:00pages
1281-5issue
8eissn
0031-9422issn
1873-3700pii
S0031-9422(01)00174-1journal_volume
57pub_type
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