Abstract:
:Two sulfur-containing compounds, (S)-2-amino-5-((R)-1-carboxy-2-((E)-3-(4-hydroxy-3-methoxyphenyl)allylthio)ethyl-amino)-5-oxopentanoic acid (1) and (S)-2-amino-5-((R)-1-(carboxymethylamino)-3-((E)-3-(4-hydroxyphenyl)allylthio)-1-oxopropan-2-ylamino)-5-oxopentanoic acid (2), and one 1H-pyrrole-2-carboxylic acid derivative, 6-(3-(1H-pyrrole-2-carbonyloxy)-2-hydroxypropoxy)-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-carboxylic acid (3), together with eighteen known phenolic compounds, were isolated from the fruits of pineapple. Their structures were elucidated by a combination of spectroscopic analyses. Some of these compounds showed inhibitory activities against tyrosinase. The half maximal inhibitory concentration values of compounds 1, 4, 5, 6, 7 are lower than 1 mM. These compounds may contribute to the well-known anti-browning effect of pineapple juice and be potential skin whitening agents in cosmetic applications.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Zheng ZP,Ma J,Cheng KW,Chao J,Zhu Q,Chang RC,Zhao M,Lin ZX,Wang Mdoi
10.1016/j.phytochem.2010.08.014subject
Has Abstractpub_date
2010-12-01 00:00:00pages
2046-51issue
17-18eissn
0031-9422issn
1873-3700pii
S0031-9422(10)00314-6journal_volume
71pub_type
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