Abstract：
:Eleven oleanane-type triterpenoid saponins, foegraecumosides A-K, and eight known ones, were isolated from the aerial parts of Lysimachia foenum-graecum. Their structures were elucidated by spectroscopic data analyses and chemical methods. All isolated saponins were evaluated for their cytotoxicity against four human cancer cell lines (NCI-H460, MGC-803, HepG2, and T24). Seven saponins containing the aglycone cyclamiretin A exhibited moderate cytotoxicity against all tested human cancer cell lines, with IC50 values of 9.3-24.5 μM. Simultaneously, the cytotoxic activities of foegraecumosides A and B, lysichriside A, ardisiacrispins A and B, cyclaminorin, and 3-O-α-L-rhamnopyranosyl-(1 → 2)-β-d-glucopyranosyl-(1 → 4)-α-l-arabinopyranosyl-cyclamiretin A were tested on drug-resistant lung cancer cell lines (A549 and A549/CDDP, respectively). Ardisiacrispin B displayed moderate cytotoxicity against A549/CDDP, with an IC50 value of 8.7 μM and a resistant factor (RF) of 0.9.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Dai LM,Huang RZ,Zhang B,Hua J,Wang HS,Liang Ddoi
10.1016/j.phytochem.2017.01.021subject
Has Abstractpub_date
2017-04-01 00:00:00pages
165-174eissn
0031-9422issn
1873-3700pii
S0031-9422(17)30039-0journal_volume
136pub_type
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