Abstract：
:Six previously undescribed tropane alkaloids, designated as erythrobezerrines A-F, were isolated from the EtOH extract from the stem bark of Erythroxylum bezerrae Plowman. Their structures were elucidated based on the interpretation of the NMR and MS data and in some instances, confirmed by X-ray diffraction analysis. The cytotoxicity of the isolated compounds was evaluated against the cancer cell lines L929, PC-3, HCT-116, SNB-19 and NCI-H460, but only erythrobezerrine C showed moderate activity with IC50 values of 3.38 and 5.43 μM for HCT-116 and NCI-H460, respectively.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Brito LSO,Pinto FDCL,de Filho MOM,Rocha DD,Mendoza MFM,Ayala AP,Bezerra BP,Loiola MIB,Canuto KM,Silveira ER,Pessoa ODLdoi
10.1016/j.phytochem.2020.112458subject
Has Abstractpub_date
2020-10-01 00:00:00pages
112458eissn
0031-9422issn
1873-3700pii
S0031-9422(19)31213-0journal_volume
178pub_type
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