Abstract:
:Five 3,4-seco-cycloartane triterpenoids were isolated from the stems of Kadsura ananosma, two of which had rearranged 5/6 consecutive carbocycle rings C/D (trivially named ananosins A (1) and B (2)), one had a migrated CH3-18 (named ananosins C (3)), and two were analogs, ananosins D (4) and E (5). Their structures were characterized by comprehensive spectroscopic analysis, especially using 2D NMR spectra. A biogenetic pathway to 1 was proposed. These 5 compounds, together with 5 known analogs isolated from the same origin, were evaluated for their cytotoxicity against HL-60, SMMC-7721, A-549, PANC-1, and SK-BR-3 human cancer cells, but were inactive.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Yang JH,Pu JX,Wen J,Li XN,He F,Su J,Li Y,Sun HDdoi
10.1016/j.phytochem.2014.10.014subject
Has Abstractpub_date
2015-01-01 00:00:00pages
36-42eissn
0031-9422issn
1873-3700pii
S0031-9422(14)00418-Xjournal_volume
109pub_type
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