Antiplasmodial activity of sesquilignans and sesquineolignans from Bonamia spectabilis.

Abstract:

:Phytochemical re-investigation of the aerial parts of Bonamia spectabilis (Convolvulaceae) led to the isolation of four minor tetrahydrofuran-type sesquilignans (bonaspectins E-H) together with the known neolignan virolongin A and the known lignan rel-(7S,8R,7'R,8'R)-3,3',4,4',5,5'-hexamethoxylignan. Their structures were established on the basis of spectral data. These six compounds as well as further seven lignanoids from B. spectabilis, characterised previously, were tested for their antiplasmodial activity against a chloroquine-sensitive strain (PoW) and a chloroquine-resistant clone (Dd2) of Plasmodium falciparum. Bonaspectin C 4"-O-glucoside, its aglycone, and bonaspectin D 4"-O-glucoside revealed the highest antiplasmodial activities (IC50 values: 1.3, 2.0, 6.5 microM [PoW]; 1.7, 4.6, 3.7 microM [Dd2], respectively).

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Kraft C,Jenett-Siems K,Köhler I,Tofern-Reblin B,Siems K,Bienzle U,Eich E

doi

10.1016/s0031-9422(02)00101-2

subject

Has Abstract

pub_date

2002-05-01 00:00:00

pages

167-73

issue

2

eissn

0031-9422

issn

1873-3700

pii

S0031942202001012

journal_volume

60

pub_type

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