Abstract:
:Phytochemical re-investigation of the aerial parts of Bonamia spectabilis (Convolvulaceae) led to the isolation of four minor tetrahydrofuran-type sesquilignans (bonaspectins E-H) together with the known neolignan virolongin A and the known lignan rel-(7S,8R,7'R,8'R)-3,3',4,4',5,5'-hexamethoxylignan. Their structures were established on the basis of spectral data. These six compounds as well as further seven lignanoids from B. spectabilis, characterised previously, were tested for their antiplasmodial activity against a chloroquine-sensitive strain (PoW) and a chloroquine-resistant clone (Dd2) of Plasmodium falciparum. Bonaspectin C 4"-O-glucoside, its aglycone, and bonaspectin D 4"-O-glucoside revealed the highest antiplasmodial activities (IC50 values: 1.3, 2.0, 6.5 microM [PoW]; 1.7, 4.6, 3.7 microM [Dd2], respectively).
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Kraft C,Jenett-Siems K,Köhler I,Tofern-Reblin B,Siems K,Bienzle U,Eich Edoi
10.1016/s0031-9422(02)00101-2subject
Has Abstractpub_date
2002-05-01 00:00:00pages
167-73issue
2eissn
0031-9422issn
1873-3700pii
S0031942202001012journal_volume
60pub_type
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