Triterpenes derived from hydrolyzate of total Gynostemma pentaphyllum saponins with anti-hepatic fibrosis and protective activity against H2O2-induced injury.

Abstract:

:Gynostemma pentaphyllum is a popular functional food, and it is also used as a traditional medicine in Asia. In this study, five previously undescribed triterpenes, gypensapogenin M, gypensapogenin N, gypensapogenin O, gypensapogenin P, and gypensapogenin Q, together with five known compounds were isolated from the hydrolyzate of total G. pentaphyllum saponins. The bioassay data showed that all the triterpenes exhibited significant protective activity against H2O2-induced myocardial cell injury and anti-hepatic fibrosis activity. Taken together, the discovery of these triterpenes from the hydrolyzate of total G. pentaphyllum saponins expands its use as a functional food for preventing myocardial injury and liver fibrosis.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Zhang X,Shi G,Sun Y,Wu X,Zhao Y

doi

10.1016/j.phytochem.2017.09.021

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

226-232

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(17)30326-6

journal_volume

144

pub_type

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