Study of sesquiterpene lactones from Milleria quinqueflora on their anti-inflammatory activity using the transcription factor NF-kappa B as molecular target.

Abstract:

:In Central America aerial parts of the Asteraceae Milleria quinqueflora are used in traditional medicine as a remedy for skin infections. Reinvestigation of this plant afforded thirteen sesquiterpene lactones (Sls), three of them are new. All isolated Sls were studied for their anti-inflammatory activity using the transcription factor NF-kappa B as molecular target. NF-kappa B is involved in the synthesis of inflammatory mediators, such as cytokines and chemokines. NF-kappa B DNA binding was inhibited at micromolar concentrations by all Sls.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Castro V,Rüngeler P,Murillo R,Hernandez E,Mora G,Pahl HL,Merfort I

doi

10.1016/s0031-9422(99)00510-5

subject

Has Abstract

pub_date

2000-01-01 00:00:00

pages

257-63

issue

2

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(99)00510-5

journal_volume

53

pub_type

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