Abstract:
:In Central America aerial parts of the Asteraceae Milleria quinqueflora are used in traditional medicine as a remedy for skin infections. Reinvestigation of this plant afforded thirteen sesquiterpene lactones (Sls), three of them are new. All isolated Sls were studied for their anti-inflammatory activity using the transcription factor NF-kappa B as molecular target. NF-kappa B is involved in the synthesis of inflammatory mediators, such as cytokines and chemokines. NF-kappa B DNA binding was inhibited at micromolar concentrations by all Sls.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Castro V,Rüngeler P,Murillo R,Hernandez E,Mora G,Pahl HL,Merfort Idoi
10.1016/s0031-9422(99)00510-5subject
Has Abstractpub_date
2000-01-01 00:00:00pages
257-63issue
2eissn
0031-9422issn
1873-3700pii
S0031-9422(99)00510-5journal_volume
53pub_type
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