Abstract：
:Bioguided-fractionation of an acetone extract of the roots of Salvia cilicica (Lamiaceae) led to isolation of two new diterpenes, 7-hydroxy-12-methoxy-20-nor-abieta-1,5(10),7,9,12-pentaen-6,14-dione and abieta-8,12-dien-11,14-dione (12-deoxy-royleanone), together with oleanolic acid, ursolic acid, ferruginol, inuroyoleanol and cryptanol. Their structures were determined spectroscopically, which included HREIMS and 2D NMR spectroscopic analysis. The new abietane derivatives showed appreciable in vitro antileishmanial activity against intracellular amastigote forms of both Leishmania donovani (IC(50) values of 170 and 120 nM, respectively) and Leishmania major (IC(50) values of 290 and 180 nM, respectively). The triterpenoic acids were found to be potently active against amastigote (IC(50) values of 7-120 nM) and moderately active against promastigote stages (IC(50) values of 51-137 nM) of the two Leishmania species.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Tan N,Kaloga M,Radtke OA,Kiderlen AF,Oksüz S,Ulubelen A,Kolodziej Hdoi
10.1016/s0031-9422(02)00361-8subject
Has Abstractpub_date
2002-12-01 00:00:00pages
881-4issue
8eissn
0031-9422issn
1873-3700pii
S0031942202003618journal_volume
61pub_type
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