Abstract：
:6,8-Dimethoxy-3-(2'-oxo-propyl)-coumarin (1) and 2,4-dihydroxy-6-[(1'E,3'E)-penta-1',3'-dienyl]-benzaldehyde (2), in addition to the known compound periconicin B (3), were isolated from the ethyl acetate extract of Periconia atropurpurea, an endophytic fungus obtained from the leaves of Xylopia aromatica, a native plant of the Brazilian Cerrado. Their chemical structures were assigned based on analyses of MS, 1D and 2D-NMR spectroscopic experiments. Biological analyses were performed using two mammalian cell lines, human cervix carcinoma (HeLa) and Chinese hamster ovary (CHO). The results showed that compound 1 had no effect when compared to the control group, which was treated with the vehicle (DMSO). Compound 2 was able to induce a slight increase in cell proliferation of HeLa (37% of increase) and CHO (38% of increase) cell lines. Analysis of compound 3 showed that it has potent cytotoxic activity against both cell lines, with an IC50 of 8.0 microM. Biological analyses using the phytopathogenic fungi Cladosporium sphaerospermum and C. cladosporioides revealed that also 2 showed potent antifungal activity compared to nystatin.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Teles HL,Sordi R,Silva GH,Castro-Gamboa I,Bolzani Vda S,Pfenning LH,de Abreu LM,Costa-Neto CM,Young MC,Araújo ARdoi
10.1016/j.phytochem.2006.09.005subject
Has Abstractpub_date
2006-12-01 00:00:00pages
2686-90issue
24eissn
0031-9422issn
1873-3700pii
S0031-9422(06)00569-3journal_volume
67pub_type
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