Interconverting flavonostilbenes with antibacterial activity from Sophora alopecuroides.

Abstract:

:Five flavonostilbenes (alopecurones H, I, J, K and L) and five known ones were isolated from roots of Sophora alopecuroides, in addition to ten other phenolic compounds. A non-enzymatic interconversion of the lavandulyl-substituted flavonostilbenes was observed among alopecurones A, H, I, and K through a Wessely-Moser rearrangement reaction; this was proven by 1D and 2D NMR, HPLC-CD-PDA and HRMS analyses. Bioassay results suggested that flavonostilbenes exhibit significant antibacterial and anti-biofilm formation activities against Staphylococcus epidermidis with MIC values ranging from 3.1 to 12.5μg/mL.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Wan CX,Luo JG,Ren XP,Kong LY

doi

10.1016/j.phytochem.2015.02.022

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

290-297

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(15)00088-6

journal_volume

116

pub_type

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