Inhibitors of platelet lipoxygenase from Ponkan fruit.

Abstract:

:An activity-guided separation for inhibitors of rat platelet 12-lipoxygenase led to the isolation of two compounds, 4-O-feruloyl-5-O-caffeoylquinic acid (IC50; 5.5 microM) and methyl 4-O-feruloyl-5-O-caffeoylquinate (IC50; 1.9 microM) from the peel of Ponkan fruit (Citrus reticulata). The complete structure of each phenolic ester was determined by NMR spectroscopy [1H and 13C NMR spectra, 1H-1H correlation spectroscopy (COSY), 1H-detected heteronuclear multiple quantum coherence (HMQC), and heteronuclear multiple bond connectivity (HMBC) spectroscopies] and other spectral methods.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Nogata Y,Sekiya K,Ohta H,Kusumoto K,Ishizu T

doi

10.1016/s0031-9422(00)00462-3

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

729-32

issue

7

eissn

0031-9422

issn

1873-3700

pii

S0031942200004623

journal_volume

56

pub_type

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