Abstract：
:Six cardenolides were isolated from the anti-tumor active fraction of the 75% ethanol extract of Streptocaulon juventas (Asclepiadaceae), mainly found in southwest of China. These were named 1α, 14β-dihydroxy-5β-card-20 (22)-enolide 3-O-[O-β-D-glucopyranosyl-(1→2)-β-D-digitalopyranoside] (1), acovenosigenin A 3-O-[O-β-D-glucopyranosyl-(1→4)-β-D-digitalopyranoside] (2), 16-O-acetyl-hydroxyperiplogenin 3-O-β-D-digitoxopyranoside (3), digitoxigenin 3-O-[O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranosyl-(1→4)-2-O-acetyl-β-D-digitalopyranoside] (4), 16-O-acetyl-hydroxyacovenosigenin (5), 1β, 3β, 14β-trihydroxy-5β-card-16, 20 (22)-dienolide (6), together with 18 known ones, most of which had never been reported in the species beforehand. Their structures were elucidated on the basis of spectroscopic studies and comparison with reference. Eighteen compounds were evaluated for their cytotoxicity against human lung A549 adenocarcinoma cell lines.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Xue R,Han N,Ye C,Wang HB,Yin Jdoi
10.1016/j.phytochem.2012.12.004subject
Has Abstractpub_date
2013-04-01 00:00:00pages
105-11eissn
0031-9422issn
1873-3700pii
S0031-9422(12)00524-9journal_volume
88pub_type
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