An anti-staphylococcal acylphloroglucinol from Hypericum foliosum.

Abstract:

:An investigation into the antibacterial properties of Hypericum foliosum Aiton. (Guttiferae) has led to the isolation of a new bioactive acylphloroglucinol natural product which by NMR spectroscopy and mass spectrometry was characterised as 1,3,5-trihydroxy-6-[2''',3'''-epoxy-3'''-methyl-butyl]-2-[2''-methyl-butanoyl]-4-[3'-methyl-2''-butenyl]-benzene and is described here for the first time. This metabolite was evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus and minimum inhibitory values ranged from 16 to 32 microg/ml.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Gibbons S,Moser E,Hausmann S,Stavri M,Smith E,Clennett C

doi

10.1016/j.phytochem.2005.04.024

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

1472-5

issue

12

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(05)00188-3

journal_volume

66

pub_type

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