Phenylpropanoid glucosides from leaves of Coussarea hydrangeifolia (Rubiaceae).

Abstract:

:Phenylpropanoid glycosides, 1'-O-benzyl-alpha-L-rhamnopyranosyl-(1''-->6')-beta-D-glucopyranoside (1) and alpha-L-xylopyranosyl-(4''-->2')-(3-O-beta-D-glucopyranosyl)-1'-O-E-caffeoyl-beta-D-glucopyranoside (2), together with the known derivatives, 1,6-di-O-caffeoyl-beta-D-glucopyranoside (3), 1-O-(E)-caffeoyl-beta-D-glucopyranoside (4) and 1-O-(E)-feruloyl-beta-D-glucopyranoside (5), were isolated from leaves of Coussarea hydrangeifolia. Their structures were determined by IR, HRESIMS, and 1D and 2D NMR experiments, and their antioxidant activities, evaluated by assaying the free radical scavenging capacity using the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical as substrate. The antioxidant activities of 3 and 4 (IC50 values of 15.0 and 19.2 microM, respectively) were comparable to that of the standard positive control caffeic acid, whilst 2 and 5 were only weakly active and 1 was inactive.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Hamerski L,Bomm MD,Silva DH,Young MC,Furlan M,Eberlin MN,Castro-Gamboa I,Cavalheiro AJ,da Silva Bolzani V

doi

10.1016/j.phytochem.2005.06.019

subject

Has Abstract

pub_date

2005-08-01 00:00:00

pages

1927-32

issue

16

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(05)00294-3

journal_volume

66

pub_type

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