Abstract：
:Phytochemical investigation of the flowers of Inula japonica led to isolation of nine sesquiterpenoids, inujaponins A-I, as well as eighteen known ones. These sesquiterpenoids belong to six skeletal-types, including eudesmane, 1,10-seco-eudesmane, germacrane, guaiane, 4,5-seco-guaiane, and pseudoguaiane sesquiterpenoids. Their structures were established by extensive spectroscopic analysis. The absolute configurations of inujaponin A, eupatolide, and deacetylovatifolin were determined by Cu-Kα X-ray crystallographic analysis. Most of the isolated compounds exhibited potent cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cancer cell lines, with IC50 values ranging from 1.57 to 22.58 μM. Some selected compounds also possessed significant inhibitory activity against LPS-induced NO production in RAW264.7 macrophages with IC50 values ranging from 1.42 to 8.99 μM.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Wu XD,Ding LF,Tu WC,Yang H,Su J,Peng LY,Li Y,Zhao QSdoi
10.1016/j.phytochem.2016.07.008subject
Has Abstractpub_date
2016-09-01 00:00:00pages
68-76eissn
0031-9422issn
1873-3700pii
S0031-9422(16)30135-2journal_volume
129pub_type
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