Abstract:
:Two mulinane-type diterpenoids were isolated from Azorella compacta; namely 20-hydroxymulin-11,13-dienyl acetate and 13,14-dihydroxymulin-11-en-20-oic acid. The structures were elucidated by analysis of their spectroscopic data. These compounds, as well as three previously isolated diterpenes, were evaluated as potential in vivo growth inhibitors of Plasmodium berghei NK 65 on infected mice at an intraperitoneal dose of 10 mg/kg/day. Sixty percent and forty-two percent growth inhibition were obtained with 17-acetoxymulin-11,13-dien-20-oic acid and 13, 14-dihydroxymulin-11-en-20-oic acid, respectively.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Loyola LA,Bórquez J,Morales G,San-Martín A,Darias J,Flores N,Giménez Adoi
10.1016/j.phytochem.2004.06.011subject
Has Abstractpub_date
2004-07-01 00:00:00pages
1931-5issue
13eissn
0031-9422issn
1873-3700pii
S0031942204002602journal_volume
65pub_type
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