Mulinane-type diterpenoids from Azorella compacta display antiplasmodial activity.

Abstract:

:Two mulinane-type diterpenoids were isolated from Azorella compacta; namely 20-hydroxymulin-11,13-dienyl acetate and 13,14-dihydroxymulin-11-en-20-oic acid. The structures were elucidated by analysis of their spectroscopic data. These compounds, as well as three previously isolated diterpenes, were evaluated as potential in vivo growth inhibitors of Plasmodium berghei NK 65 on infected mice at an intraperitoneal dose of 10 mg/kg/day. Sixty percent and forty-two percent growth inhibition were obtained with 17-acetoxymulin-11,13-dien-20-oic acid and 13, 14-dihydroxymulin-11-en-20-oic acid, respectively.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Loyola LA,Bórquez J,Morales G,San-Martín A,Darias J,Flores N,Giménez A

doi

10.1016/j.phytochem.2004.06.011

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

1931-5

issue

13

eissn

0031-9422

issn

1873-3700

pii

S0031942204002602

journal_volume

65

pub_type

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