Abstract：
:From the petroleum ether extract of the rhizomes of Tamus communis, the 7-hydroxy-2,3,4,8-tetramethoxyphenanthrene (1) was isolated, together with the known 2,3,4-trimethoxy-7,8-methylenedioxyphenanthrene (2), 3-hydroxy-2,4,-dimethoxy-7,8-methylenedioxyphenanthrene (3), 2-hydroxy-3,5,7-trimethoxyphenanthrene (4) and 2-hydroxy-3,5,7-trimethoxy-9,10-dihydrophenanthrene (5), through cytotoxic assay guidance. The structures were determined by means of HREIMS, (1)H NMR, JMOD and NOESY experiments. The cytotoxic effects of the isolated compounds were tested on cervix adenocarcinoma (HeLa) cells, with the MTT assay. The results demonstrated that, with the exception of 2, all these compounds displayed pronounced cytotoxic activity; especially 1 and 3 exhibited significant cell growth inhibitory effects, with IC(50)=8.52+/-0.70 and 3.64+/-0.12 microM, respectively.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Kovács A,Forgo P,Zupkó I,Réthy B,Falkay G,Szabó P,Hohmann Jdoi
10.1016/j.phytochem.2006.10.028subject
Has Abstractpub_date
2007-03-01 00:00:00pages
687-91issue
5eissn
0031-9422issn
1873-3700pii
S0031-9422(06)00686-8journal_volume
68pub_type
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