Phenanthrenes and a dihydrophenanthrene from Tamus communis and their cytotoxic activity.

Abstract:

:From the petroleum ether extract of the rhizomes of Tamus communis, the 7-hydroxy-2,3,4,8-tetramethoxyphenanthrene (1) was isolated, together with the known 2,3,4-trimethoxy-7,8-methylenedioxyphenanthrene (2), 3-hydroxy-2,4,-dimethoxy-7,8-methylenedioxyphenanthrene (3), 2-hydroxy-3,5,7-trimethoxyphenanthrene (4) and 2-hydroxy-3,5,7-trimethoxy-9,10-dihydrophenanthrene (5), through cytotoxic assay guidance. The structures were determined by means of HREIMS, (1)H NMR, JMOD and NOESY experiments. The cytotoxic effects of the isolated compounds were tested on cervix adenocarcinoma (HeLa) cells, with the MTT assay. The results demonstrated that, with the exception of 2, all these compounds displayed pronounced cytotoxic activity; especially 1 and 3 exhibited significant cell growth inhibitory effects, with IC(50)=8.52+/-0.70 and 3.64+/-0.12 microM, respectively.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Kovács A,Forgo P,Zupkó I,Réthy B,Falkay G,Szabó P,Hohmann J

doi

10.1016/j.phytochem.2006.10.028

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

687-91

issue

5

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(06)00686-8

journal_volume

68

pub_type

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