Phenanthrenes and a dihydrophenanthrene from Tamus communis and their cytotoxic activity.


:From the petroleum ether extract of the rhizomes of Tamus communis, the 7-hydroxy-2,3,4,8-tetramethoxyphenanthrene (1) was isolated, together with the known 2,3,4-trimethoxy-7,8-methylenedioxyphenanthrene (2), 3-hydroxy-2,4,-dimethoxy-7,8-methylenedioxyphenanthrene (3), 2-hydroxy-3,5,7-trimethoxyphenanthrene (4) and 2-hydroxy-3,5,7-trimethoxy-9,10-dihydrophenanthrene (5), through cytotoxic assay guidance. The structures were determined by means of HREIMS, (1)H NMR, JMOD and NOESY experiments. The cytotoxic effects of the isolated compounds were tested on cervix adenocarcinoma (HeLa) cells, with the MTT assay. The results demonstrated that, with the exception of 2, all these compounds displayed pronounced cytotoxic activity; especially 1 and 3 exhibited significant cell growth inhibitory effects, with IC(50)=8.52+/-0.70 and 3.64+/-0.12 microM, respectively.






Kovács A,Forgo P,Zupkó I,Réthy B,Falkay G,Szabó P,Hohmann J




Has Abstract


2007-03-01 00:00:00














  • Interconverting flavonostilbenes with antibacterial activity from Sophora alopecuroides.

    abstract::Five flavonostilbenes (alopecurones H, I, J, K and L) and five known ones were isolated from roots of Sophora alopecuroides, in addition to ten other phenolic compounds. A non-enzymatic interconversion of the lavandulyl-substituted flavonostilbenes was observed among alopecurones A, H, I, and K through a Wessely-Moser...


    pub_type: 杂志文章


    authors: Wan CX,Luo JG,Ren XP,Kong LY

    更新日期:2015-08-01 00:00:00

  • Iridal glycosides from Iris spuria (Zeal), cultivated in Egypt.

    abstract::Fractionation of a methanol extract obtained from rhizomes of I. spuria (Zeal) resulted in the isolation of seven iridalglycosides 5a,b, 6a-c, 7, 8. The structures of the aglycons and the position of the glycosidic bonds were elucidated by spectroscopic analyses. The nature of the sugar moieties was determined as gluc...


    pub_type: 杂志文章


    authors: Marner FJ,Singab AN,Al-Azizi MM,El-Emary NA,Schäfer M

    更新日期:2002-06-01 00:00:00

  • The S8 serine, C1A cysteine and A1 aspartic protease families in Arabidopsis.

    abstract::The Arabidopsis thaliana genome has over 550 protease sequences representing all five catalytic types: serine, cysteine, aspartic acid, metallo and threonine (MEROPS peptidase database,, which probably reflect a wide variety of as yet unidentified functions performed by plant proteases. Re...


    pub_type: 杂志文章


    authors: Beers EP,Jones AM,Dickerman AW

    更新日期:2004-01-01 00:00:00

  • Triumphalone, a diketone from the volatile oil of the leaves of Melaleuca triumphalis, and its spontaneous conversion into isotriumphalone.

    abstract::The major component (35-65%) of the volatile oil obtained by steam distillation of the leaves of Melaleuca triumphalis has been identified as (rel)-1beta-pentyl-1alpha,6alpha-dihydroxy-3,3,5,5-tetramethylcyclohexa-2,4-dione (trivial name triumphalone). Relative stereochemistry was established by nuclear Overhauser exp...


    pub_type: 杂志文章


    authors: Brophy JJ,Craig DC,Goldsack RJ,Fookes CJ,Leach DN,Waterman PG

    更新日期:2006-09-01 00:00:00

  • Naphthoquinone metabolites of the fungi.

    abstract::Structures and physico-chemical properties of 100 naphthoquinone metabolites produced by filamentous fungi are reviewed. The conditions of pigment formation, biogenesis and the mechanism of biosynthesis of pigments by fungi are described. Sixty-three fungi cultures able to produce naphthoquinone are listed. The biolog...


    pub_type: 杂志文章,评审


    authors: Medentsev AG,Akimenko VK

    更新日期:1998-03-01 00:00:00

  • Production of bioactive triterpenes by Eriobotrya japonica calli.

    abstract::Callus tissue cultures induced from an axenic leaf of Eriobotrya japonica (Rosaceae) produced triterpenes in large amounts (ca. 50 mg/g dry wt). Nine triterpenes were characterized as ursolic acid, oleanolic acid, 2alpha-hydoxyursolic acid, maslinic acid, tormentic acid, 2alpha, 19alpha-dihydroxy-3-oxo-urs-12-en-28-oi...


    pub_type: 杂志文章


    authors: Taniguchi S,Imayoshi Y,Kobayashi E,Takamatsu Y,Ito H,Hatano T,Sakagami H,Tokuda H,Nishino H,Sugita D,Shimura S,Yoshida T

    更新日期:2002-02-01 00:00:00

  • A flavonoid from Brassica rapa flower as the UV-absorbing nectar guide.

    abstract::The corolla of Brassica rapa has an UV-absorbing zone in its center, known as the nectar guide for attracting pollinating insects. The pigment which plays the role of the nectar guide was isolated from the petals and identified to be isorhamnetin 3,7-O-di-beta-D-glucopyranoside on the basis of MS and NMR spectroscopic...


    pub_type: 杂志文章


    authors: Sasaki K,Takahashi T

    更新日期:2002-10-01 00:00:00

  • Patterns of phenylpropanoids in non-inoculated and potato virus Y-inoculated leaves of transgenic tobacco plants expressing yeast-derived invertase.

    abstract::The patterns of secondary metabolites in leaves of yeast invertase-transgenic tobacco plants (Nicotiana tabacum L. cv. Samsun NN) were analyzed. Plants expressing cytosolic yeast-derived invertase (cytInv) or apoplastic (cell wall associated) yeast invertase (cwInv) showed a characteristic phytochemical phenotype comp...


    pub_type: 杂志文章


    authors: Baumert A,Mock HP,Schmidt J,Herbers K,Sonnewald U,Strack D

    更新日期:2001-03-01 00:00:00

  • Glucosinolates, flea beetle resistance, and leaf pubescence as taxonomic characters in the genus Barbarea (Brassicaceae).

    abstract::Glucosinolate content of leaves and roots, diversity in leaf pubescence, and resistance to two near-isogenic lines of the flea beetle Phyllotreta nemorum with or without an R-gene, were determined for 27 accessions of 7 Barbarea taxa, i.e. B. stricta, B. orthoceras, B. intermedia, B. verna, B. vulgaris var. vulgaris, ...


    pub_type: 杂志文章


    authors: Agerbirk N,Ørgaard M,Nielsen JK

    更新日期:2003-05-01 00:00:00

  • The AOC promoter of tomato is regulated by developmental and environmental stimuli.

    abstract::The allene oxide cyclase (AOC) catalyzes the formation of cis-(+)-12-oxophytodienoic acid, an intermediate in jasmonate biosynthesis and is encoded by a single copy gene in tomato. The full length AOC promoter isolated by genome walk contains 3600 bp. Transgenic tomato lines carrying a 1000 bp promoter fragment and th...


    pub_type: 杂志文章


    authors: Stenzel I,Hause B,Proels R,Miersch O,Oka M,Roitsch T,Wasternack C

    更新日期:2008-06-01 00:00:00

  • Chemotaxonomy of the Oleaceae: iridoids as taxonomic markers.

    abstract::The distribution and biosynthesis of iridoid glucosides in the Oleaceae is reviewed and five distinct biosynthetic pathways to iridoids have been identified in the family, deoxyloganic acid apparently being a common intermediate. Likewise, the distributions of caffeoyl phenylethanoid glycosides (CPGs), i.e. verbascosi...


    pub_type: 杂志文章,评审


    authors: Jensen SR,Franzyk H,Wallander E

    更新日期:2002-06-01 00:00:00

  • Flavanone glycosides from Alhagi pseudalhagi.

    abstract::Two new flavanone glycosides, alhagitin and alhagidin, have been isolated from the whole plant of Alhagi pseudalhagi and their structures established respectively as naringenin 5-methyl ether 4'-glucoside and hesperitin 7-galactosyl(1-->2)[rhamnosyl(1-->6)]glucoside by chemical and spectroscopic methods. ...


    pub_type: 杂志文章


    authors: Singh VP,Yadav B,Pandey VB

    更新日期:1999-06-01 00:00:00

  • Differential inhibition of Helicoverpa armigera gut proteinases by proteinase inhibitors of pigeonpea (Cajanus cajan) and its wild relatives.

    abstract::The seeds of 36 pigeonpea [Cajanus cajan (L) Millsp.] cultivars, resistant and susceptible to pests and pathogens and 17 of its wild relatives were analysed for inhibitors of trypsin, chymotrypsin, and insect gut proteinases to identify potential inhibitors of insect (Helicoverpa armigera) gut enzymes. Proteinase inhi...


    pub_type: 杂志文章


    authors: Chougule NP,Hivrale VK,Chhabda PJ,Giri AP,Kachole MS

    更新日期:2003-10-01 00:00:00

  • Essential oils from Azorean Laurus azorica.

    abstract::The essential oils isolated from leaves of ten and from unripe berries of eight populations of Laurus azorica (Seub.) Franco, collected on five islands of the Azorean archipelago, were analysed by GC and GC-MS. All oil samples were dominated by their monoterpene fraction (60-94%), alpha-pinene (15-37%) and 1,8-cineole...


    pub_type: 杂志文章


    authors: Pedro LG,Santos PA,da Silva JA,Figueiredo AC,Barroso JG,Deans SG,Looman A,Scheffer JJ

    更新日期:2001-05-01 00:00:00

  • Dammarane-type glycosides from Gynostemma pubescens.

    abstract::Triterpene saponins 1-8 were isolated from the aerial parts of Gynostemma pubescens. Among them, compounds 1-4, 8 possess carboxylic groups at both C-21 and C-29, 5 contains a carboxylic group at C-21 and an aldehyde function at C-29, whereas 6 and 7 contain carboxylic groups at C-21 and hydroxymethylene groups at C-2...


    pub_type: 杂志文章


    authors: Yang Z,Chen Q,Hu L

    更新日期:2007-07-01 00:00:00

  • Bioactive terpenoids from sunflower leaves cv. Peredovick.

    abstract::The CH(2)Cl(2) extract of dried leaves of Helianthus annuus L. cv. Peredovick(R) has yielded, in addition to the known sesquiterpene lactones annuolide E and leptocarpin, and the sesquiterpenes heliannuols A, C, D, F, G, H, I, the new bisnorsesquiterpene, annuionone E, and the new sesquiterpenes heliannuol L, helibisa...


    pub_type: 杂志文章


    authors: Macías FA,Torres A,Galindo JL,Varela RM,Alvarez JA,Molinillo JM

    更新日期:2002-11-01 00:00:00

  • Functional characterization of two acyltransferases from Populus trichocarpa capable of synthesizing benzyl benzoate and salicyl benzoate, potential intermediates in salicinoid phenolic glycoside biosynthesis.

    abstract::Salicinoids are phenolic glycosides (PGs) characteristic of the Salicaceae and are known defenses against insect herbivory. Common examples are salicin, salicortin, tremuloidin, and tremulacin, which accumulate to high concentrations in the leaves and bark of willows and poplars. Although their biosynthetic pathway is...


    pub_type: 杂志文章


    authors: Chedgy RJ,Köllner TG,Constabel CP

    更新日期:2015-05-01 00:00:00

  • Iodus 40, salicylic acid, heptanoyl salicylic acid and trehalose exhibit different efficacies and defence targets during a wheat/powdery mildew interaction.

    abstract::Prophylactic efficacies of Iodus 40 and salicylic acid (SA) against wheat powdery mildew caused by Blumeria graminis f. sp. tritici have been shown and compared with those of heptanoyl salicylic acid (HSA) and trehalose. Plantlets treated once exhibited 55%, 50%, 95%, and 38% protection levels, respectively. Two spray...


    pub_type: 杂志文章


    authors: Renard-Merlier D,Randoux B,Nowak E,Farcy F,Durand R,Reignault P

    更新日期:2007-04-01 00:00:00

  • Flavonol glycosides from Calotropis gigantea.

    abstract::Besides isolation and characterization of isorhamnetin-3-O-rutinoside, isorhamnetin-3-O-glucopyranoside and taraxasteryl acetate, a new flavonol trisaccharide was isolated from the aerial parts of Calotropis gigantea, and its structure was established as isorhamnetin-3-O-[2-O-beta-D-galactopyranosyl-6-O-alpha-L-rhamno...


    pub_type: 杂志文章


    authors: Sen S,Sahu NP,Mahato SB

    更新日期:1992-08-01 00:00:00

  • Cordifolisides A, B, C: norditerpene furan glycosides from Tinospora cordifolia.

    abstract::Several glycosides were isolated, as polyacetates, from the n-BuOH fraction of the Tinospora cordifolia stems. The structures of three new norditerpene furan glycosides cordifoliside A, B and C have been established by 1D and 2D NMR spectroscopy. ...


    pub_type: 杂志文章


    authors: Gangan VD,Pradhan P,Sipahimalani AT,Banerji A

    更新日期:1994-10-01 00:00:00

  • Anti-inflammatory guaiane-type sesquiterpenes from the fruits of Pittosporum undulatum.

    abstract::Two unprecedented guaiane-type sesquiterpene glycosides (undulatumosides A and B) were isolated by bioassay-guided fractionation from the MeOH extract of Pittosporum undulatum fruits, along with six known compounds, including the guaiane isomers 5-guaien-11-ol and 4-guaien-11-ol. The structures of the compounds were e...


    pub_type: 杂志文章


    authors: Mendes SA,Mansoor TA,Rodrigues A,Armas JB,Ferreira MJ

    更新日期:2013-11-01 00:00:00

  • Direct fungicidal activities of C6-aldehydes are important constituents for defense responses in Arabidopsis against Botrytis cinerea.

    abstract::C6-aldehydes, such as (Z)-3-hexenal, (E)-2-hexenal, and n-hexanal, are volatile compounds formed by hydroperoxide lyase (HPL) and found in most terrestrial plants. They are fungicidal and bactericidal compounds, and are also signaling compounds to induce defense responses in plants. Transgenic plants having overexpres...


    pub_type: 杂志文章


    authors: Kishimoto K,Matsui K,Ozawa R,Takabayashi J

    更新日期:2008-08-01 00:00:00

  • Covalent binding of chloroacetamide herbicides to the active site cysteine of plant type III polyketide synthases.

    abstract::Chloroacetamide herbicides inhibit very-long-chain fatty acid elongase, and it has been suggested that covalent binding to the active site cysteine of the condensing enzyme is responsible [Pest Manage Sci 56 (2000), 497], but direct evidence was not available. The proposal implied that other condensing enzymes might a...


    pub_type: 杂志文章


    authors: Eckermann C,Matthes B,Nimtz M,Reiser V,Lederer B,Böger P,Schröder J

    更新日期:2003-11-01 00:00:00

  • Steroidal saponins from the leaves of Cordyline stricta.

    abstract::Three new spirostanol saponins and two new furostanol saponins were isolated from the fresh leaves of Cordyline stricta. Their structures were elucidated on the basis of spectroscopic analysis, including various 2D NMR techniques, hydrolysis, and by comparison of spectral data of known compounds. Two of the isolated s...


    pub_type: 杂志文章


    authors: Mimaki Y,Kuroda M,Takaashi Y,Sashida Y

    更新日期:1998-01-01 00:00:00

  • Lignans from Saururus chinensis inhibiting the transcription factor NF-kappaB.

    abstract::The sesquineolignans, saucerneol D and saucerneol E were isolated from the roots of Saururus chinensis together with four known lignans, manassantin A, manassantin B, (-)-saucerneol methyl ether, and (+)-saucernetin. Structure elucidation was based on the analysis of spectroscopic data and anti-inflammatory activity w...


    pub_type: 杂志文章


    authors: Hwang BY,Lee JH,Nam JB,Hong YS,Lee JJ

    更新日期:2003-10-01 00:00:00

  • Isolation and structure elucidation of tetrameric procyanidins from unripe apples (Malus pumila cv. Fuji) by NMR spectroscopy.

    abstract::Procyanidins are plant secondary metabolites widely consumed and known to have various physiological functions, but their bioavailability and mechanism of action are still unclear especially for larger oligomers. One of the reasons is scarce information about the detailed structure of oligomeric procyanidins. As for a...


    pub_type: 杂志文章


    authors: Nakashima S,Oda C,Masuda S,Tagashira M,Kanda T

    更新日期:2012-11-01 00:00:00

  • A arylnaphthalene lignan from Haplophyllum buxbaumii.

    abstract::Haplophyllum buxbaumii has yielded a new diphyllin glycoside, which was characterized as 4-O-{bis-alpha-L-xylopyranosyl (1-->2, 1-->5) beta-D-apiofuranosyloxy}-6,7-dimethoxy-1-(3,4-methylenedioxyphenyl)-3-hydroxymethyl naphthalene-2-carboxylic acid lactone. Taiwanin-H is also reported for the first time from a member ...


    pub_type: 杂志文章


    authors: Al-Abed Y,Abu-Zarga M,Sabri S,Atta-Ur-Rahman,Voelter W

    更新日期:1998-11-20 00:00:00

  • Biosynthesis of tetrahydroanthraquinones in fungi.

    abstract::The tetrahydroanthraquinones (1S,3S)-austrocortilutein (4) and (1S,3S)-austrocortirubin (7) are octaketides formed in the fruit bodies of the fungus Dermocybe splendida via the gentiobioside 2 of the dihydroanthracenone (S)-torosachrysone (1). ...


    pub_type: 杂志文章


    authors: Elsworth C,Gill M,Saubern S

    更新日期:2000-09-01 00:00:00

  • Phytotoxic triterpene saponins from Bellis longifolia, an endemic plant of Crete.

    abstract::In a study of 62 plant species of the Cretan flora for their phytotoxic activity, plants were extracted successively with CH2Cl2, MeOH and H2O. Phytotoxicity evaluation of the 240 extracts was performed against Lactuca sativa L. and Agrostis stolonifera L.. The MeOH extract of Bellis longifolia was the most phytotoxic...


    pub_type: 杂志文章


    authors: Stavropoulou MI,Angelis A,Aligiannis N,Kalpoutzakis E,Mitakou S,Duke SO,Fokialakis N

    更新日期:2017-12-01 00:00:00

  • Diterpenoid glucosides from Salvia greggii.

    abstract::The structure of four diterpenoid glucosides, designated as salvigresides A-D (1-4), isolated from the aerial parts of Salvia greggii, have been confirmed by spectroscopic and chemical investigation. ...


    pub_type: 杂志文章


    authors: Kawahara N,Tamura T,Inoue M,Hosoe T,Kawai K,Sekita S,Satake M,Goda Y

    更新日期:2004-09-01 00:00:00