Abstract:
:Seven previously undescribed polyketides, namely childinins A-G, and one previously undescribed 8,14-seco-ergosterol, namely childinasterone A, were obtained from the fruiting bodies of Daldinia childiae. Their structures and absolute configurations were established via extensive spectroscopic analyses, single-crystal X-ray diffraction, and TDDFT/ECD calculations. Childinins A represents the first example of natural product possessing a previously undescribed 6H-naphtho[2,1-c]chromen-6-one scaffold. The single crystal X-ray diffraction of childinasterone A unambiguously determined the absolute configuration of a 8,14-seco-ergosterol skeleton. Childinins A, B, F and G (MIC90 54.9 μg⋅mL-1) showed anti-bacterial activities. Childinasterone A showed significant anti-NO activity (IC50 21.2 μM) and weak activities against SMMC-7721, MCF-7 and SW480 cell lines.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Zhao ZZ,Chen HP,Huang Y,Zhang SB,Li ZH,Feng T,Liu JKdoi
10.1016/j.phytochem.2017.06.020subject
Has Abstractpub_date
2017-10-01 00:00:00pages
68-75eissn
0031-9422issn
1873-3700pii
S0031-9422(17)30250-9journal_volume
142pub_type
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