Bioactive polyketides and 8,14-seco-ergosterol from fruiting bodies of the ascomycete Daldinia childiae.

Abstract:

:Seven previously undescribed polyketides, namely childinins A-G, and one previously undescribed 8,14-seco-ergosterol, namely childinasterone A, were obtained from the fruiting bodies of Daldinia childiae. Their structures and absolute configurations were established via extensive spectroscopic analyses, single-crystal X-ray diffraction, and TDDFT/ECD calculations. Childinins A represents the first example of natural product possessing a previously undescribed 6H-naphtho[2,1-c]chromen-6-one scaffold. The single crystal X-ray diffraction of childinasterone A unambiguously determined the absolute configuration of a 8,14-seco-ergosterol skeleton. Childinins A, B, F and G (MIC90 54.9 μg⋅mL-1) showed anti-bacterial activities. Childinasterone A showed significant anti-NO activity (IC50 21.2 μM) and weak activities against SMMC-7721, MCF-7 and SW480 cell lines.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Zhao ZZ,Chen HP,Huang Y,Zhang SB,Li ZH,Feng T,Liu JK

doi

10.1016/j.phytochem.2017.06.020

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

68-75

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(17)30250-9

journal_volume

142

pub_type

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