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Oleanane-type triterpene saponins with collagen synthesis-promoting activity from the flowers of Bellis perennis.

Abstract：

:The methanol extract from Bellis perennis (Asteraceae) flowers was found to promote collagen synthesis in normal human dermal fibroblasts (NHDFs). Seven oleanane-type triterpene saponins, perennisosides XIII-XIX, and two known saponins, bellissaponins BS5 and BS9, were isolated from the methanol extract. The structures were determined based on chemical and physicochemical data, and confirmed using previously isolated related compounds as references. Among the isolates, including 19 previously reported saponins, perennisosides XVIII, I, II, VII, IX, and XI, asterbatanoside D, bernardioside B2, and bellissaponins BS5 and BS9 significantly promoted collagen synthesis at 3-30μM without cytotoxicity.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Morikawa T,Ninomiya K,Takamori Y,Nishida E,Yasue M,Hayakawa T,Muraoka O,Li X,Nakamura S,Yoshikawa M,Matsuda H

doi

10.1016/j.phytochem.2015.05.011

subject

Has Abstract

pub_date

2015-08-01 00:00:00

pages

203-212

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(15)00172-7

journal_volume

116

pub_type

杂志文章

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