Sesquiterpene lactones from Elephantopus mollis and their anti-inflammatory activities.

Abstract:

:Seven sesquiterpene lactones, 8-O-methacryloylelephanpane, 2,4-bis-O-methyl-8-O-methacryloylelephanpane, 4-O-ethyl-8-O-methacryloylelephanpane, 8-O-methacryloylisoelephanpane, 2-O-demethyltomenphantopin C, molephantin A, molephantin B, along with ten known ones, were isolated from Elephantopus mollis (Asteraceae). Their structures were elucidated by extensive analysis of spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR). The isolates were evaluated for their anti-inflammatory activities on LPS-stimulated RAW 264.7 cells, and all tested compounds exhibited potent anti-inflammatory effects with IC50 values of 0.57 ± 0.17 to 14.34 ± 1.61 μM, except that compound tomenphantopin C exhibited moderate anti-inflammatory activity with IC50 values of 59.97 ± 1.53 μM.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Wu ZN,Zhang YB,Chen NH,Li MJ,Li MM,Tang W,Zhuang L,Li YL,Wang GC

doi

10.1016/j.phytochem.2017.01.020

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

81-86

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(17)30038-9

journal_volume

137

pub_type

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