Abstract:
:Seven sesquiterpene lactones, 8-O-methacryloylelephanpane, 2,4-bis-O-methyl-8-O-methacryloylelephanpane, 4-O-ethyl-8-O-methacryloylelephanpane, 8-O-methacryloylisoelephanpane, 2-O-demethyltomenphantopin C, molephantin A, molephantin B, along with ten known ones, were isolated from Elephantopus mollis (Asteraceae). Their structures were elucidated by extensive analysis of spectroscopic data (IR, UV, HRESIMS, 1D and 2D NMR). The isolates were evaluated for their anti-inflammatory activities on LPS-stimulated RAW 264.7 cells, and all tested compounds exhibited potent anti-inflammatory effects with IC50 values of 0.57 ± 0.17 to 14.34 ± 1.61 μM, except that compound tomenphantopin C exhibited moderate anti-inflammatory activity with IC50 values of 59.97 ± 1.53 μM.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Wu ZN,Zhang YB,Chen NH,Li MJ,Li MM,Tang W,Zhuang L,Li YL,Wang GCdoi
10.1016/j.phytochem.2017.01.020subject
Has Abstractpub_date
2017-05-01 00:00:00pages
81-86eissn
0031-9422issn
1873-3700pii
S0031-9422(17)30038-9journal_volume
137pub_type
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