Abstract:
:From the hexane extract of berries of Juniperus excelsa, one new and four known diterpenes were isolated besides a known sesquiterpene. The structures of the known diterpenes were identified as isopimaric, isocommunic, (-)ent-trans communic and sandracopimaric acids, along with the sesquiterpene 4a-hydroxycedrol and the new compound which was elucidated as 3 alpha-acetoxylabda-8(17),13(16),14-trien-19-oic acid (juniperexcelsic acid). Cytotoxic activity of the hexane extract was investigated against a panel of cell line and found highly active against LNCaP, KB-V (+VLB) and KB-V (-VLB) cell lines. Furthermore, the hexane and methanol extracts, and the new compound were found to be moderately active against Mycobacterium tuberculosis.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Topçu G,Erenler R,Cakmak O,Johansson CB,Celik C,Chai HB,Pezzuto JMdoi
10.1016/s0031-9422(98)00675-xsubject
Has Abstractpub_date
1999-04-01 00:00:00pages
1195-9issue
7eissn
0031-9422issn
1873-3700pii
S0031-9422(98)00675-Xjournal_volume
50pub_type
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