Diterpenes from the berries of Juniperus excelsa.

Abstract:

:From the hexane extract of berries of Juniperus excelsa, one new and four known diterpenes were isolated besides a known sesquiterpene. The structures of the known diterpenes were identified as isopimaric, isocommunic, (-)ent-trans communic and sandracopimaric acids, along with the sesquiterpene 4a-hydroxycedrol and the new compound which was elucidated as 3 alpha-acetoxylabda-8(17),13(16),14-trien-19-oic acid (juniperexcelsic acid). Cytotoxic activity of the hexane extract was investigated against a panel of cell line and found highly active against LNCaP, KB-V (+VLB) and KB-V (-VLB) cell lines. Furthermore, the hexane and methanol extracts, and the new compound were found to be moderately active against Mycobacterium tuberculosis.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Topçu G,Erenler R,Cakmak O,Johansson CB,Celik C,Chai HB,Pezzuto JM

doi

10.1016/s0031-9422(98)00675-x

subject

Has Abstract

pub_date

1999-04-01 00:00:00

pages

1195-9

issue

7

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(98)00675-X

journal_volume

50

pub_type

杂志文章
  • A variable loop involved in the substrate selectivity of pinoresinol/lariciresinol reductase from Camellia sinensis.

    abstract::Pinoresinol/lariciresinol reductase (PLR), an NADPH-dependent reductase that catalyzes the sequential reduction of pinoresinol into secoisolariciresinol via Lariciresinol, can lead to the structural and stereochemical diversity of lignans. The relationship between substrate-selective reaction of PLR and sequence homol...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/j.phytochem.2019.02.003

    authors: Wu Y,Xing D,Ma G,Dai X,Gao L,Xia T

    更新日期:2019-06-01 00:00:00

  • Acylated triterpene saponins from Silene jenisseensis.

    abstract::From the roots of Silene jenisseensis a new trans-p-methoxycinnamoyl triterpene saponin has been isolated along with its cis-p-methoxycinnamoyl isomer as an inseparable mixture. Their structures were established by chemical means and spectroscopic methods including 1D- and 2D-homonuclear and heteronuclear correlation ...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/0031-9422(95)00222-s

    authors: Lacaille-Dubois MA,Hanquet B,Cui ZH,Lou ZC,Wagner H

    更新日期:1995-09-01 00:00:00

  • Sequential oxidation of Jasmonoyl-Phenylalanine and Jasmonoyl-Isoleucine by multiple cytochrome P450 of the CYP94 family through newly identified aldehyde intermediates.

    abstract::The role and fate of Jasmonoyl-Phenylalanine (JA-Phe), an understudied conjugate in the jasmonate pathway remain to be unraveled. We addressed here the possibility of JA-Phe oxidative turnover by cytochrome P450s of the CYP94 family. Leaf wounding or fungal infection in Arabidopsis resulted in accumulation of JA-Phe, ...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/j.phytochem.2015.06.027

    authors: Widemann E,Grausem B,Renault H,Pineau E,Heinrich C,Lugan R,Ullmann P,Miesch L,Aubert Y,Miesch M,Heitz T,Pinot F

    更新日期:2015-09-01 00:00:00

  • Non-indolyl cruciferous phytoalexins: Nasturlexins and tridentatols, a striking convergent evolution of defenses in terrestrial plants and marine animals?

    abstract::Highly specialized chemical defense pathways are a particularly noteworthy metabolic characteristic of sessile organisms, whether terrestrial or marine, providing protection against pests and diseases. For this reason, knowledge of the metabolites involved in these processes is crucial to producing ecologically fit cr...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/j.phytochem.2014.07.024

    authors: Pedras MS,To QH

    更新日期:2015-05-01 00:00:00

  • Iridal glycosides from Iris spuria (Zeal), cultivated in Egypt.

    abstract::Fractionation of a methanol extract obtained from rhizomes of I. spuria (Zeal) resulted in the isolation of seven iridalglycosides 5a,b, 6a-c, 7, 8. The structures of the aglycons and the position of the glycosidic bonds were elucidated by spectroscopic analyses. The nature of the sugar moieties was determined as gluc...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/s0031-9422(02)00110-3

    authors: Marner FJ,Singab AN,Al-Azizi MM,El-Emary NA,Schäfer M

    更新日期:2002-06-01 00:00:00

  • alpha-D-Glucuronosyl-(1-->3)-L-galactose, an unusual disaccharide from polysaccharides of the hornwort Anthoceros caucasicus.

    abstract::Acid hydrolysis of cell wall-rich material from thalli of the hornwort Anthoceros caucasicus yielded substantial amounts of an unusual disaccharide (1). Hydrolysis of 1 yielded only GlcA, Gal and unhydrolysed 1. Compound 1 was identified as alpha-D-GlcpA-(1-->3)-L-Gal by 1H and 13C NMR spectroscopic analysis and by th...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/s0031-9422(03)00330-3

    authors: Popper ZA,Sadler IH,Fry SC

    更新日期:2003-09-01 00:00:00

  • Ecdysteroids and bufadienolides from Helleborus torquatus (Ranunculaceae).

    abstract::Three bufadienolides, hellebortin A (5-[beta-D-glucopyranosyloxy]-10,14,16-trihydroxy-19-nor-[5beta,10beta,14beta,16beta]-bufa-3,20,22-trienolide [1]), hellebortin B (5-[beta-D-glucopyranosyloxy]-3,4-epoxy-14-hydroxy-19-oxo-bufa-20,22-dienolide [2]) and hellebortin C (5-[beta-D-glucopyranosyloxy]-3,4-epoxy-10,14-dihyd...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/s0031-9422(01)00070-x

    authors: Meng Y,Whiting P,Sik V,Rees HH,Dinan L

    更新日期:2001-06-01 00:00:00

  • Functional characterization of domains in AtTRB1, a putative telomere-binding protein in Arabidopsis thaliana.

    abstract::Telomeres are nucleoprotein structures ensuring the stability of eukaryotic chromosome ends. Two protein families, TRFL (TFL-Like) and SMH (Single-Myb-Histone), containing a specific telobox motif in their Myb domain, have been identified as potential candidates involved in a functional nucleoprotein structure analogo...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/j.phytochem.2008.04.001

    authors: Mozgová I,Schrumpfová PP,Hofr C,Fajkus J

    更新日期:2008-06-01 00:00:00

  • Roscotanes and roscoranes: Oxygenated abietane and pimarane diterpenoids from Kaempferia roscoeana.

    abstract::Eight previously undescribed ditepenoids, including four oxygenated abietanes (roscotanes A-D) and four oxygenated pimaranes (roscoranes A-D), along with twelve known diterpenoids were isolated from the whole plants of Kaempferia roscoeana. Their structures were elucidated by extensive spectroscopic analysis, and the ...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/j.phytochem.2017.07.008

    authors: Boonsombat J,Mahidol C,Chawengrum P,Reuk-Ngam N,Chimnoi N,Techasakul S,Ruchirawat S,Thongnest S

    更新日期:2017-11-01 00:00:00

  • Cyanogenic glucosides and plant-insect interactions.

    abstract::Cyanogenic glucosides are phytoanticipins known to be present in more than 2500 plant species. They are considered to have an important role in plant defense against herbivores due to bitter taste and release of toxic hydrogen cyanide upon tissue disruption. Some specialized herbivores, especially insects, preferentia...

    journal_title:Phytochemistry

    pub_type: 杂志文章,评审

    doi:10.1016/j.phytochem.2003.10.016

    authors: Zagrobelny M,Bak S,Rasmussen AV,Jørgensen B,Naumann CM,Lindberg Møller B

    更新日期:2004-02-01 00:00:00

  • Oleanane triterpenes with protein tyrosine phosphatase 1B inhibitory activity from aerial parts of Lantana camara collected in Indonesia and Japan.

    abstract::During the search for new protein tyrosine phosphatase (PTP) 1B inhibitors, EtOH extracts from the aerial parts of Lantana camara L. (lantana) collected at Manado (Indonesia) and two subtropical islands in Japan (Ishigaki and Iriomote Islands, Okinawa) exhibited potent inhibitory activities against PTP1B in an enzyme ...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/j.phytochem.2017.08.020

    authors: Abdjul DB,Yamazaki H,Maarisit W,Rotinsulu H,Wewengkang DS,Sumilat DA,Kapojos MM,Losung F,Ukai K,Namikoshi M

    更新日期:2017-12-01 00:00:00

  • 3 alpha-hydroxy-oleanane-type triterpene glycosyl esters from leaves of Acanthopanax spinosus.

    abstract::Three novel 3 alpha-hydroxy-oleanane-type triterpene oligoglycosyl esters, spinoside C1, C4 and C5, were isolated from the leaves of Acanthopanax spinosus. The structures were established to be 28-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glucopyranosyl (1-->6)-beta-D-glucopyranosyl esters of 3 alpha, 29-dihydroxy-olean...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/s0031-9422(00)90853-7

    authors: Miyakoshi M,Ida Y,Isoda S,Shoji J

    更新日期:1993-12-01 00:00:00

  • Analysis of commercial proanthocyanidins. Part 2: An electrospray mass spectrometry investigation into the chemical composition of sulfited quebracho (Schinopsis lorentzii and Schinopsis balansae) heartwood extract.

    abstract::Proanthocyanidins (PACs) are natural plant-derived polymers used in leather tanning, wood adhesives, water purification, and mud additives for oil drilling. Quebracho (Schinopsis lorentzii and Schinopsis balansae) heartwood and mimosa (Acacia mearnsii) bark extracts are the major industrial sources of PACs. These comm...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/j.phytochem.2012.01.027

    authors: Venter PB,Senekal ND,Amra-Jordaan M,Bonnet SL,Van der Westhuizen JH

    更新日期:2012-06-01 00:00:00

  • Rapid isolation and identification of minor natural products by LC-MS, LC-SPE-NMR and ECD: isoflavanones, biflavanones and bisdihydrocoumarins from Ormocarpum kirkii.

    abstract::The combination of the hyphenated techniques LC-MS and LC-SPE-NMR constitutes a powerful platform for the rapid isolation and identification of minor components from natural sources. Electronic circular dichroism (ECD) is a useful tool to determine the absolute configuration of small quantities of chiral molecules. In...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/j.phytochem.2012.04.004

    authors: Xu YJ,Foubert K,Dhooghe L,Lemière F,Maregesi S,Coleman CM,Zou Y,Ferreira D,Apers S,Pieters L

    更新日期:2012-07-01 00:00:00

  • Discovery of small molecule inhibitors of xyloglucan endotransglucosylase (XET) activity by high-throughput screening.

    abstract::Small molecules (xenobiotics) that inhibit cell-wall-localised enzymes are valuable for elucidating the enzymes' biological roles. We applied a high-throughput fluorescent dot-blot screen to search for inhibitors of Petroselinum xyloglucan endotransglucosylase (XET) activity in vitro. Of 4216 xenobiotics tested, with ...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/j.phytochem.2015.06.016

    authors: Chormova D,Franková L,Defries A,Cutler SR,Fry SC

    更新日期:2015-09-01 00:00:00

  • Alkaloids from Dictyoloma vandellianum: their chemosystematic significance.

    abstract::The dichloromethane extract from leaves of Dictyoloma vandellianum afforded five alkaloids 2-(14'-hydroxy-14',15'-dimethylhexadecanyl)-4-quinolone, 2-(12'-hydroxy-12'-methyltridecanyl)-3-methoxy-4-quinolone, 2-(12'-hydroxy-12'-methyltridecanyl)-4-quinolone, 2-(14'-hydroxy-14',15'-dimethylhexadecanyl)-3-methoxy-4-quino...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/s0031-9422(03)00006-2

    authors: Sartor CF,da Silva MF,Fernandes JB,Vieira PC,Fo ER,Garcia Cortez DA

    更新日期:2003-05-01 00:00:00

  • Chemotaxonomy of Portuguese Ulex: quinolizidine alkaloids as taxonomical markers.

    abstract::Six species of Portuguese Ulex L. in a total of nineteen populations were studied by GC-EIMS as to their content in quinolizidine alkaloids. Sparteine, beta-isosparteine, jussiaeiine A, N-methylcytisine, cytisine, 5,6-dehydrolupanine, rhombifoline, lupanine, jussiaeiine B, N-formylcytisine, N-acetylcytisine, anagyrine...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/j.phytochem.2006.05.037

    authors: Máximo P,Lourenço A,Tei A,Wink M

    更新日期:2006-09-01 00:00:00

  • Morphological, chemical and genetic differentiation of two subspecies of Cistus creticus L. (C. creticus subsp. eriocephalus and C. creticus subsp. corsicus).

    abstract::Cistus creticus L., an aromatic species from the Mediterranean area, contains various diterpenes bearing the labdane skeleton. The production of essential oil from this species has potential economic value, but so far, it has not been optimized. In order to contribute to a better knowledge of this species and to its d...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/j.phytochem.2009.06.013

    authors: Paolini J,Falchi A,Quilichini Y,Desjobert JM,Cian MC,Varesi L,Costa J

    更新日期:2009-06-01 00:00:00

  • Polyketide synthases of bacterial symbionts in sponges--evolution-based applications in natural products research.

    abstract::Marine sponges are an unusually rich source of bioactive natural products with clinical potential. They also often harbor rich communities of symbiotic bacteria that have often been suspected as the true producers of sponge-derived compounds. To date, these bacteria can in most cases not be cultivated, but culture-ind...

    journal_title:Phytochemistry

    pub_type: 杂志文章,评审

    doi:10.1016/j.phytochem.2009.04.010

    authors: Hochmuth T,Piel J

    更新日期:2009-10-01 00:00:00

  • Cyclic fatty acyl glycosides in the glandular trichome exudate of Silene gallica.

    abstract::Chemical investigation of the glandular trichome exudate from Silene gallica L. (Caryophyllaceae) resulted in isolation of 10 cyclic fatty acyl glycosides (gallicasides A-J). The cyclic structures were characterized by a glycosidic linkage of the glucose moiety to either the C-12 or the C-13 position of the octadecano...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/j.phytochem.2010.05.008

    authors: Asai T,Fujimoto Y

    更新日期:2010-08-01 00:00:00

  • Phenylpropanoid glucosides from Chrozophora obliqua.

    abstract::From the aerial parts of Chrozophora obliqua, two phenylpropanoid glucosides: 4-O-methyl guaiacylglycerol 9-O-beta-glucopyranoside (1) and 4-O-methyl guaiacylglycerol 8-O-beta-glucopyranoside (2) together with syringin, benzyl alcohol glucoside, isorhamnetin-3-O-beta-glucopyranoside-7-O-alpha-rhamnopyranoside and quer...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/s0031-9422(01)00262-x

    authors: Mohamed KM

    更新日期:2001-10-01 00:00:00

  • Study of sesquiterpene lactones from Milleria quinqueflora on their anti-inflammatory activity using the transcription factor NF-kappa B as molecular target.

    abstract::In Central America aerial parts of the Asteraceae Milleria quinqueflora are used in traditional medicine as a remedy for skin infections. Reinvestigation of this plant afforded thirteen sesquiterpene lactones (Sls), three of them are new. All isolated Sls were studied for their anti-inflammatory activity using the tra...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/s0031-9422(99)00510-5

    authors: Castro V,Rüngeler P,Murillo R,Hernandez E,Mora G,Pahl HL,Merfort I

    更新日期:2000-01-01 00:00:00

  • Iridoids from Caryopteris x clandonensis.

    abstract::In continuation of our phytochemical studies on Caryopteris x clandonensis (Lamiaceae), three further iridoids were isolated from the methanolic extract of the stems. Their structures were established by 1D and 2D NMR and MS analysis as a C-6 epimer of 8-O-acetylharpagide (6-epi-8-O-acetylharpagide), a derivative of h...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/s0031-9422(00)00069-8

    authors: Hannedouche S,Stanislas E,Moulis C,Fourasté I

    更新日期:2000-08-01 00:00:00

  • Chromones and anthrones from Aloe marlothii and Aloe rupestris.

    abstract::A phytochemical investigation of the leaf exudate of Aloe marlothii has resulted in the isolation of a new chromone (7-O-methylaloeresin A) and a new anthrone (5-hydroxyaloin A 6'-O-acetate). Furthermore 7-O-methylaloesin was isolated as a natural product for the first time from the leaf exudate of Aloe rupestris. The...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/s0031-9422(00)00328-9

    authors: Bisrat D,Dagne E,van Wyk BE,Viljoen A

    更新日期:2000-12-01 00:00:00

  • Antibacterial and resistance modifying activity of Rosmarinus officinalis.

    abstract::As part of a project to characterise plant-derived natural products that modulate bacterial multidrug resistance (MDR), bioassay-guided fractionation of a chloroform extract of the aerial parts of Rosmarinus officinalis led to the characterisation of the known abietane diterpenes carnosic acid (1), carnosol (2) and 12...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/j.phytochem.2004.10.009

    authors: Oluwatuyi M,Kaatz GW,Gibbons S

    更新日期:2004-12-01 00:00:00

  • Cycloartane triterpenoids from Guarea macrophylla.

    abstract::Nine cycloartane triterpenoids, including two new derivatives 22,25-dihydroxy-cycloart-23E-en-3-one and 24-methylenecycloartane-3 beta,22-diol have been isolated from leaves of Guarea macrophylla. The structures were elucidated by interpretation of spectral data, mainly 1H and 13C NMR, including bidimensional analysis...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/s0031-9422(02)00123-1

    authors: Lago JH,Roque NF

    更新日期:2002-06-01 00:00:00

  • Immunosuppressive pregnane glycosides from Periploca sepium and Periploca forrestii.

    abstract::Nine pregnane glycosides containing peroxy functions in their sugar moieties (1-5 and 11-14), five oligosaccharides (6-10), six pregnane glycosides (15-20), and five cardiac glycosides (21-25) were isolated from the root barks of Periploca sepium Bge. (Asclepiadaceae) and the roots of Periploca forrestii Schltr. (Ascl...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/j.phytochem.2008.08.015

    authors: Feng J,Zhang R,Zhou Y,Chen Z,Tang W,Liu Q,Zuo JP,Zhao W

    更新日期:2008-11-01 00:00:00

  • Triterpenoids from the stems and leaves of Schisandra incarnata.

    abstract::Six undescribed triterpenoids, schincarins A‒F, categorized as the preschisanartane (schincarin A), 3,4-secocycloartane (schincarins B‒D), 3,4; 9,10-disecocycloartane (schincarin E), and 3,4-secolanostane (schincarin F) classes, along with twelve known analogues, were obtained from the stems and leaves of Schisandra i...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/j.phytochem.2020.112448

    authors: Zhou M,Peng X,Zhou J,Liu Y,Meng X,Ruan H

    更新日期:2020-09-01 00:00:00

  • Isolation and synthesis of chalcones with different degrees of saturation.

    abstract::Crotaoprostrin, a chalcone not yet known as a plant constituent, was isolated from the aerial parts of the Indian medicinal plant Crotalaria prostrata. The structures of the chalcone polyarvin and the partially hydrogenated naturally occurring derivatives crotaramin, crotaramosmin, and crotin were confirmed by chemica...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/s0031-9422(02)00475-2

    authors: Krohn K,Steingröver K,Srinivasa Rao M

    更新日期:2002-12-01 00:00:00

  • Ester-type cephalotaxus alkaloids from Cephalotaxus harringtonia var. drupacea.

    abstract::Three alkaloids, neoharringtonine, homoneoharringtonine and 3'S-hydroxyneoharringtonine, were isolated from the leaves and stems of Cephalotaxus harringtonia var. drupacea. Their structures were established by spectroscopic methods, including two-dimensional NMR and CD spectra, and their antileukaemic activity was eva...

    journal_title:Phytochemistry

    pub_type: 杂志文章

    doi:10.1016/s0031-9422(96)00574-2

    authors: Takano I,Yasuda I,Nishijima M,Yanagi Y,Takeya K,Itokawa H

    更新日期:1997-02-01 00:00:00