Cladocalol, a pentacyclic 28-nor-triterpene from Eucalyptus cladocalyx with cytotoxic activity.

Abstract:

:A formylated triterpene named cladocalol has been isolated from the leaves of Eucalyptus cladocalyx, together with ursulolactone acetate, ursolic acid, 3 beta-acetate-12,20(29)-lupadien-28-oic acid, beta-sitosterol and the known flavonoid eucalyptine. Their structures were mainly established by extensive NMR studies (1H NMR, 13C NMR, DEPT, 1H-1H COSY, HSQC, HMBC) and mass spectroscopy as well as by X-ray crystallographic analysis. In this paper, we report on the cytotoxic effect induced by cladocalol and its derivatives on the myeloid leukemia cell line HL-60.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Benyahia S,Benayache S,Benayache F,León F,Quintana J,López M,Hernández JC,Estévez F,Bermejo J

doi

10.1016/j.phytochem.2004.12.018

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

627-32

issue

6

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(04)00641-7

journal_volume

66

pub_type

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