Five labdane diterpenoids from the seeds of Aframomum zambesiacum.

Abstract:

:Five labdane diterpenoids, (3-5), zambesiacolactone A (7) and zambesiacolactone B (8), were isolated from the seeds of Aframomum zambesiacum (Baker) K. Schum., along with five known labdanes and a linear sesquiterpene, nerolidol. Their structures were elucidated by spectroscopic analysis. Their antiplasmodial activity was evaluated in vitro against Plasmodium falciparum. Compound 3 was the most active with an IC(50) value of 4.97 microM.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Kenmogne M,Prost E,Harakat D,Jacquier MJ,Frédérich M,Sondengam LB,Zèches M,Waffo-Téguo P

doi

10.1016/j.phytochem.2005.10.015

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

433-8

issue

5

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(05)00545-5

journal_volume

67

pub_type

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