Abstract：
:Maytenus aquifolium (Celastraceae) and Salacia campestris (Hippocrateaceae) species accumulate friedelane and quinonemethide triterpenoids in their leaves and root bark, respectively. Enzymatic extracts obtained from leaves displayed cyclase activity with conversion of the substrate oxidosqualene to the triterpenes, 3beta-friedelanol and friedelin. In addition, administration of (+/-)5-(3)H mevalonolactone in leaves of M. aquifolium seedlings produced radio labelled friedelin in the leaves, twigs and stems, while the root bark accumulated labelled maytenin and pristimerin. These experiments indicated that the triterpenes once biosynthesized in the leaves are translocated to the root bark and further transformed to the antitumoral quinonemethide triterpenoids.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Corsino J,de Carvalho PR,Kato MJ,Latorre LR,Oliveira OM,Araújo AR,Bolzani VD,França SC,Pereira AM,Furlan Mdoi
10.1016/s0031-9422(00)00285-5subject
Has Abstractpub_date
2000-12-01 00:00:00pages
741-8issue
7eissn
0031-9422issn
1873-3700pii
S0031-9422(00)00285-5journal_volume
55pub_type
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