Microbial transformation of papaveraldine.

Abstract:

:Preparative-scale fermentation of papaveraldine (1), the known benzylisoquinoline alkaloid, with Mucor ramannianus 1839 (sih) has resulted in a stereoselective reduction of the ketone group and the isolation of S-papaverinol (2) and S-papaverinol N-oxide (3). The structure elucidation of both metabolites was based primarily on 1D-, 2D-NMR analyses and chemical transformations. The absolute configuration of 2 was determined using Horeau's method of asymmetric esterification. These metabolism results were consistent with the previous plant cell transformation studies on papaverine and isopapaverine.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

El Sayed KA

doi

10.1016/s0031-9422(99)00616-0

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

675-8

issue

6

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(99)00616-0

journal_volume

53

pub_type

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