Abstract:
:Andrographolide, a diterpene lactone, is isolated from Andrographis paniculata which is well known for its medicinal properties. The biosynthetic route to andrographolide was studied using [1-(13)C]acetate, [2-(13)C]acetate and [1,6-(13)C(2)]glucose. The peak enrichment of eight carbon atoms in the (13)C NMR spectra of andrographolide suggested that deoxyxylulose pathway (DXP) is the major biosynthetic pathway to this diterpene. The contribution of the mevalonic acid pathway (MVA) is indicated by the observed (13)C-labeling pattern, and because the labeling patterns indicate a simultaneous contribution of both methyl erythritol phosphate (MEP) and MVA pathways it can be deduced that cross-talk occurs between plastids and cytoplasm.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Srivastava N,Akhila Adoi
10.1016/j.phytochem.2010.05.022subject
Has Abstractpub_date
2010-08-01 00:00:00pages
1298-304issue
11-12eissn
0031-9422issn
1873-3700pii
S0031-9422(10)00216-5journal_volume
71pub_type
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