Corynanthean, eburnan, secoleuconoxine, and pauciflorine alkaloids from Kopsia pauciflora.

Abstract:

:Eleven indole alkaloids, comprising four corynanthean, two eburnane, one aspidofractinine, one secoleuconoxine, one andranginine, and two pauciflorine type alkaloids were isolated from the stem-bark and leaf extracts of Kopsia pauciflora. Their structures were determined using NMR and MS analyses. The catharinensine type alkaloid kopsirensine B and the secoleuconoxine alkaloid arboloscine A showed moderate to weak activity in reversing MDR in vincristine-resistant KB cells. The alkaloid content was markedly different compared to that of a sample from Malaysian Borneo.

journal_name

Phytochemistry

journal_title

Phytochemistry

authors

Gan CY,Yoganathan K,Sim KS,Low YY,Lim SH,Kam TS

doi

10.1016/j.phytochem.2014.09.014

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

234-42

eissn

0031-9422

issn

1873-3700

pii

S0031-9422(14)00394-X

journal_volume

108

pub_type

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