Abstract:
:Eleven indole alkaloids, comprising four corynanthean, two eburnane, one aspidofractinine, one secoleuconoxine, one andranginine, and two pauciflorine type alkaloids were isolated from the stem-bark and leaf extracts of Kopsia pauciflora. Their structures were determined using NMR and MS analyses. The catharinensine type alkaloid kopsirensine B and the secoleuconoxine alkaloid arboloscine A showed moderate to weak activity in reversing MDR in vincristine-resistant KB cells. The alkaloid content was markedly different compared to that of a sample from Malaysian Borneo.
journal_name
Phytochemistryjournal_title
Phytochemistryauthors
Gan CY,Yoganathan K,Sim KS,Low YY,Lim SH,Kam TSdoi
10.1016/j.phytochem.2014.09.014subject
Has Abstractpub_date
2014-12-01 00:00:00pages
234-42eissn
0031-9422issn
1873-3700pii
S0031-9422(14)00394-Xjournal_volume
108pub_type
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