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The Mitochondrial Basis of Aging.

Abstract：

:A decline in mitochondrial quality and activity has been associated with normal aging and correlated with the development of a wide range of age-related diseases. Here, we review the evidence that a decline in mitochondria function contributes to aging. In particular, we discuss how mitochondria contribute to specific aspects of the aging process, including cellular senescence, chronic inflammation, and the age-dependent decline in stem cell activity. Signaling pathways regulating the mitochondrial unfolded protein response and mitophagy are also reviewed, with particular emphasis placed on how these pathways might, in turn, regulate longevity. Taken together, these observations suggest that mitochondria influence or regulate a number of key aspects of aging and suggest that strategies directed at improving mitochondrial quality and function might have far-reaching beneficial effects.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Sun N,Youle RJ,Finkel T

doi

10.1016/j.molcel.2016.01.028

subject

Has Abstract

pub_date

2016-03-03 00:00:00

pages

654-666

issue

5

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(16)00081-2

journal_volume

61

pub_type

杂志文章,评审

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