Abstract:
:In this issue of Molecular Cell, Fleming et al. (2008) show that histone H2B ubiquitylation and FACT function interdependently to facilitate nucleosome reassembly during transcription elongation, thereby demonstrating that histone posttranslational modifications can provide important but transient transcriptional signaling cues.
journal_name
Mol Celljournal_title
Molecular cellauthors
Hartzog GA,Quan TKdoi
10.1016/j.molcel.2008.06.012subject
Has Abstractpub_date
2008-07-11 00:00:00pages
2-4issue
1eissn
1097-2765issn
1097-4164pii
S1097-2765(08)00430-9journal_volume
31pub_type
评论,杂志文章相关文献
MOLECULAR CELL文献大全abstract::Mirtrons are alternative precursors for microRNA biogenesis that were recently described in invertebrates. These short hairpin introns use splicing to bypass Drosha cleavage, which is otherwise essential for the generation of canonical animal microRNAs. Using computational and experimental strategies, we now establish...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.09.028
更新日期:2007-10-26 00:00:00
abstract::In this issue of Molecular Cell, Gross et al. (2016) find a CpG DNA methylation signature in blood cells of patients with chronic well-controlled HIV infection that correlates with accelerated aging. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2016.04.008
更新日期:2016-04-21 00:00:00
abstract::Group II intron RNPs are mobile genetic elements that attack and invade duplex DNA. In this work, we monitor the invasion reaction in vitro and establish a quantitative kinetic framework for the steps of this complex cascade. We find that target site specificity is achieved after DNA binding, which occurs nonspecifica...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(03)00069-8
更新日期:2003-03-01 00:00:00
abstract::Tumor cells undergo changes in metabolism to meet their energetic and anabolic needs. It is conceivable that mechanisms exist to sense these changes and link them to pathways that eradicate cells primed for cancer development. We report that the tumor suppressor p53 activates a cell death priming mechanism that senses...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2013.03.016
更新日期:2013-05-09 00:00:00
abstract::In this issue of Molecular Cell, Schmidt et al. (2009) untangle the interplay between the COP9 signalosome (CSN), cullin-associated and neddylation-dissociated 1 (CAND1) protein, and cullin-RING ubiquitin ligases (CRLs). ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2009.08.011
更新日期:2009-09-11 00:00:00
abstract::DnaA occupies only the three highest-affinity binding sites in E. coli oriC throughout most of the cell cycle. Immediately prior to initiation of chromosome replication, DnaA interacts with additional recognition sites, resulting in localized DNA-strand separation. These two DnaA-oriC complexes formed during the cell ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2006.09.016
更新日期:2006-11-17 00:00:00
abstract::SNAP proteins play an essential role in membrane trafficking in eukaryotic cells. They activate and recycle SNARE proteins by serving as adaptors between SNAREs and the cytosolic chaperone NSF. We have determined the crystal structure of Sec17, the yeast homolog of alpha-SNAP, to 2.9 A resolution. Sec17 is composed of...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(00)80190-2
更新日期:1999-07-01 00:00:00
abstract::Cdh1 is a well-established activator of APC/C, a RING-type ubiquitin ligase. In this issue of Molecular Cell, Wan et al. (2011) report an APC/C-independent role of Cdh1 during development as an activator for Smurf1, a HECT-type ubiquitin ligase. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2011.11.012
更新日期:2011-12-09 00:00:00
abstract::Interphase chromatin is organized into topologically associating domains (TADs). Within TADs, chromatin looping interactions are formed between DNA regulatory elements, but their functional importance for the establishment of the 3D genome organization and gene regulation during development is unclear. Using high-reso...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2018.05.032
更新日期:2018-07-05 00:00:00
abstract::ADP-ribosylation is a post-translational modification where single units (mono-ADP-ribosylation) or polymeric chains (poly-ADP-ribosylation) of ADP-ribose are conjugated to proteins by ADP-ribosyltransferases. This post-translational modification and the ADP-ribosyltransferases (also known as PARPs) responsible for it...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2015.06.012
更新日期:2015-06-18 00:00:00
abstract::In bacterial and archaeal CRISPR immune pathways, DNA sequences from invading bacteriophage or plasmids are integrated into CRISPR loci within the host genome, conferring immunity against subsequent infections. The ribonucleoprotein complex Cascade utilizes RNAs generated from these loci to target complementary "nonse...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2012.03.020
更新日期:2012-06-08 00:00:00
abstract::Serine/arginine (SR)-rich splicing factors contain an RNA binding domain and an arginine/serine (RS)-rich domain required for protein-protein interactions. In addition to their roles in the basic splicing reaction, SR proteins function as components of splicing enhancer complexes. Here, we investigate the role of RS d...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(00)80076-3
更新日期:1998-04-01 00:00:00
abstract::Copy-number changes generate phenotypic variability in health and disease. Whether organisms protect against copy-number changes is largely unknown. Here, we show that Saccharomyces cerevisiae monitors the copy number of its ribosomal DNA (rDNA) and rapidly responds to copy-number loss with the clonal amplification of...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2018.08.036
更新日期:2018-11-01 00:00:00
abstract::An exciting study in this issue reveals how binding of the microtubule associated protein TPX2 to the mitotic kinase Aurora A induces a conformational change. This moves the phosphorylated activation domain into a more compact position within the kinase core, providing a better substrate binding platform and hiding th...
journal_title:Molecular cell
pub_type: 评论,杂志文章,评审
doi:10.1016/s1097-2765(03)00405-2
更新日期:2003-10-01 00:00:00
abstract::In this issue of Molecular Cell, Mariner et al. (2008) demonstrate that Alu RNA from a human SINE represses RNA polymerase II transcription during heat shock. This noncoding RNA is the first example of a "protein-like" transcription factor with a distinct modular architecture. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2008.02.001
更新日期:2008-02-29 00:00:00
abstract::Interference with nucleocytoplasmic transport is a strategy employed by certain viruses to compromise host cellular function. While it has been shown that the matrix (M) protein of the vesicular stomatitis virus (VSV) inhibits nuclear export of host cell mRNAs, the underlying mechanism has not been fully established. ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2004.11.023
更新日期:2005-01-07 00:00:00
abstract::In this issue, He et al. (2015) show how herpes virus usurps a cellular metabolic enzyme to induce RIG-I deamidation and RNA-independent activation, likely to better prevent further innate immune responses. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2015.03.021
更新日期:2015-04-02 00:00:00
abstract::In this issue of Molecular Cell, Chen et al. (2014) provide evidence that FMRP represses translation by binding the ribosome, suggesting a novel form of translational control. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2014.04.027
更新日期:2014-05-08 00:00:00
abstract::BIK protein is an initiator of mitochondrial apoptosis, and BIK expression is induced by proapoptotic signals, including DNA damage. Here, we demonstrate that 3' end processing and expression of BIK mRNA are controlled by the nuclear PI4,5P(2)-regulated poly(A) polymerase Star-PAP downstream of DNA damage. Nuclear PKC...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2011.11.017
更新日期:2012-01-13 00:00:00
abstract::Study of mutant phenotypes is a fundamental method for understanding gene function. The construction of a near-complete collection of yeast knockouts (YKO) and the unique molecular barcodes (or TAGs) that identify each strain has enabled quantitative functional profiling of Saccharomyces cerevisiae. By using these TAG...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2004.09.035
更新日期:2004-11-05 00:00:00
abstract::In this issue of Molecular Cell, Weinert et al. (2013) demonstrate that the intermediary metabolite acetyl-phosphate is an important acetyl donor that contributes to global protein acetylation in growth-arrested E. coli. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2013.07.006
更新日期:2013-07-25 00:00:00
abstract::Centromeres are specialized chromatin domains specified by the centromere-specific CENP-A nucleosome. The stable inheritance of vertebrate centromeres is an epigenetic process requiring deposition of new CENP-A nucleosomes by HJURP. We show HJURP is recruited to centromeres through a direct interaction between the HJU...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.02.014
更新日期:2016-03-03 00:00:00
abstract::MazF and MazE are components of a chromosomal toxin-antitoxin system of Escherichia coli. In this issue of Molecular Cell, Kamada et al. describe the crystal structure of a MazE/MazF heterohexamer and propose that the mechanism of toxin-antidote recognition is common to other homologous chromosomal and plasmid-borne s...
journal_title:Molecular cell
pub_type: 评论,杂志文章,评审
doi:10.1016/s1097-2765(03)00146-1
更新日期:2003-04-01 00:00:00
abstract::Epigenetic silencing of transposons by Piwi-interacting RNAs (piRNAs) constitutes an RNA-based genome defense mechanism. Piwi endonuclease action amplifies the piRNA pool by generating new piRNAs from target transcripts by a poorly understood mechanism. Here, we identified mouse Fkbp6 as a factor in this biogenesis pa...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2012.07.019
更新日期:2012-09-28 00:00:00
abstract::Both splicing factors and microRNAs are important regulatory molecules that play key roles in posttranscriptional gene regulation. By miRNA deep sequencing, we identified 40 miRNAs that are differentially expressed upon ectopic overexpression of the splicing factor SF2/ASF. Here we show that SF2/ASF and one of its upr...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2010.02.021
更新日期:2010-04-09 00:00:00
abstract::Maintaining a fluid bilayer is essential for cell signaling and survival. Lipid saturation is a key factor determining lipid packing and membrane fluidity, and it must be tightly controlled to guarantee organelle function and identity. A dedicated eukaryotic mechanism of lipid saturation sensing, however, remains elus...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2016.05.015
更新日期:2016-07-07 00:00:00
abstract::CRISPR-Cas immunity requires integration of short, foreign DNA fragments into the host genome at the CRISPR locus, a site consisting of alternating repeat sequences and foreign-derived spacers. In most CRISPR systems, the proteins Cas1 and Cas2 form the integration complex and are both essential for DNA acquisition. M...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2018.12.015
更新日期:2019-02-21 00:00:00
abstract::Polycomb group (PcG) proteins exert essential functions in the most disparate biological processes. The contribution of PcG proteins to cell commitment and differentiation relates to their ability to repress transcription of developmental regulators in embryonic stem (ES) cells and in committed cell lineages, includin...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2009.08.008
更新日期:2009-10-09 00:00:00
abstract::The Mre11-Rad50-Nbs1 (MRN) complex is a primary sensor of DNA double-strand breaks (DSBs). Upon recruitment to DSBs, it plays a critical role in catalyzing 5' --> 3' single-strand resection that is required for repair by homologous recombination (HR). Unknown mechanisms repress HR in G1 phase of the cell cycle during ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.09.009
更新日期:2007-10-12 00:00:00
abstract::Nup98 is a component of the nuclear pore that plays its primary role in the export of RNAs. Nup98 is expressed in two forms, derived from alternate mRNA splicing. Both forms are processed into two peptides through autoproteolysis mediated by the C-terminal domain of hNup98. The three-dimensional structure of the C-ter...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/s1097-2765(02)00589-0
更新日期:2002-08-01 00:00:00