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Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination.

Abstract：

:The Mre11-Rad50-Nbs1 (MRN) complex is a primary sensor of DNA double-strand breaks (DSBs). Upon recruitment to DSBs, it plays a critical role in catalyzing 5' --> 3' single-strand resection that is required for repair by homologous recombination (HR). Unknown mechanisms repress HR in G1 phase of the cell cycle during which nonhomologous end-joining (NHEJ) is the favored mode of DSB repair. Here we describe fission yeast Ctp1, so-named because it shares conserved domains with the mammalian tumor suppressor CtIP. Ctp1 is recruited to DSBs where it is essential for repair by HR. Ctp1 is required for efficient formation of RPA-coated single-strand DNA adjacent to DSBs, indicating that it functions with the MRN complex in 5' --> 3' resection. Transcription of ctp1(+) is periodic during the cell cycle, with the onset of its expression coinciding with the start of DNA replication. These data suggest that regulation of Ctp1 underlies cell-cycle control of HR.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Limbo O,Chahwan C,Yamada Y,de Bruin RA,Wittenberg C,Russell P

doi

10.1016/j.molcel.2007.09.009

subject

Has Abstract

pub_date

2007-10-12 00:00:00

pages

134-46

issue

1

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(07)00621-1

journal_volume

28

pub_type

杂志文章

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