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WTX: an unexpected regulator for p53.

Abstract：

:The WTX gene is frequently lost or mutated in Wilms tumor. In this issue of Molecular Cell, Kim et al. (2012) identify WTX modulation of p53 tumor-suppressor activity through regulation of p53 acetylation. Therefore, WTX differentially regulates the oncogenic β-catenin pathway and the tumor-suppressing p53 pathway.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Dai C,Gu W

doi

10.1016/j.molcel.2012.02.010

subject

Has Abstract

pub_date

2012-03-09 00:00:00

pages

581-2

issue

5

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(12)00167-0

journal_volume

45

pub_type

评论,杂志文章

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