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The heat shock response: life on the verge of death.

Abstract：

:Organisms must survive a variety of stressful conditions, including sudden temperature increases that damage important cellular structures and interfere with essential functions. In response to heat stress, cells activate an ancient signaling pathway leading to the transient expression of heat shock or heat stress proteins (Hsps). Hsps exhibit sophisticated protection mechanisms, and the most conserved Hsps are molecular chaperones that prevent the formation of nonspecific protein aggregates and assist proteins in the acquisition of their native structures. In this Review, we summarize the concepts of the protective Hsp network.

journal_name

Mol Cell

journal_title

Molecular cell

authors

Richter K,Haslbeck M,Buchner J

doi

10.1016/j.molcel.2010.10.006

subject

Has Abstract

pub_date

2010-10-22 00:00:00

pages

253-66

issue

2

eissn

1097-2765

issn

1097-4164

pii

S1097-2765(10)00782-3

journal_volume

40

pub_type

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