Abstract：
:Fluoxetine (Prozac) is an antidepressant that is thought to act by blocking presynaptic reuptake of the neurotransmitter serotonin. Despite widespread clinical use of fluoxetine, direct evidence for this mechanism has been difficult to obtain in vivo. We have determined that fluoxetine has an additional neuromuscular effect on C. elegans that is distinct from inhibition of serotonin reuptake. By screening for mutants resistant to this effect, we have identified seven genes. We report that two of these genes are homologous to each other and define a novel gene family that encodes over a dozen multipass transmembrane proteins. Our findings may have clinical implications for the mechanism of action of fluoxetine.
journal_name
Mol Celljournal_title
Molecular cellauthors
Choy RK,Thomas JHdoi
10.1016/s1097-2765(00)80362-7subject
Has Abstractpub_date
1999-08-01 00:00:00pages
143-52issue
2eissn
1097-2765issn
1097-4164pii
S1097-2765(00)80362-7journal_volume
4pub_type
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